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Gene Review

FGFR4  -  fibroblast growth factor receptor 4

Bos taurus

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High impact information on FGFR4

  • FGFR-4 was only observed when all follicle classes of an individual were expressing both FGF-8 and FGFR-3c [1].
  • Fgfr4 expression was restricted to theca cells in the follicle, and decreased significantly with increasing follicle size [2].
  • The expression of FGFR 1, 2 and 3 but not FGFR 4 was detected in bovine lens epithelial cells [3].

Anatomical context of FGFR4

  • FGF-8 and FGFR-3c were expressed in secondary follicles in 70% of fetuses examined, whereas FGFR-4 expression was significantly less frequent (20%) [1].
  • RT-PCR was used to analyze bovine Fgf8, Fgfr3c and Fgfr4 mRNA levels in oocytes, and granulosa and theca cells [2].

Other interactions of FGFR4

  • In the present study, we tested the hypothesis that FGF-8 and its cognate receptors (FGFR3c and FGFR4) are expressed in bovine antral follicles [2].


  1. Expression of fibroblast growth factor-8 and its cognate receptors, fibroblast growth factor receptor (FGFR)-3c and-4, in fetal bovine preantral follicles. Buratini, J., Glapinski, V.F., Giometti, I.C., Teixeira, A.B., Costa, I.B., Avellar, M.C., Barros, C.M., Price, C.A. Mol. Reprod. Dev. (2005) [Pubmed]
  2. Expression of fibroblast growth factor-8 and regulation of cognate receptors, fibroblast growth factor receptor-3c and -4, in bovine antral follicles. Buratini, J., Teixeira, A.B., Costa, I.B., Glapinski, V.F., Pinto, M.G., Giometti, I.C., Barros, C.M., Cao, M., Nicola, E.S., Price, C.A. Reproduction (2005) [Pubmed]
  3. Detection of polymorphic FGF receptor 1 mRNA in bovine lens epithelium by PCR. Marunouchi, T., Hosoya, H., Kousaka, M., Lee, X.R., Majima, Y. Biochem. Mol. Biol. Int. (1997) [Pubmed]
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