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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Theca Cells

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Disease relevance of Theca Cells


High impact information on Theca Cells

  • A luteinizing dose of LH caused a cessation of proliferation in luteinizing granulosa cells while stimulating a limited proliferation of theca cells [6].
  • Estradiol and FSH each acted on follicles at different stages of development to stimulate proliferative activity of both granulosa and theca cells [6].
  • These results indicate that, depending upon the state of differentiation of granulosa and theca cells, estradiol, FSH and LH can stimulate or inhibit the ability of these cells to proliferate [6].
  • Cultured human granulosa and theca cells did not contain mRNA for IL-1 beta or IL-1RA but did contain mRNA for IL-1R [7].
  • LH acts on theca cells via cAMP ro regulate both P450scc and P450(17) alpha mRNA levels, leading to increased biosynthesis of androstenedione [8].

Biological context of Theca Cells


Anatomical context of Theca Cells


Associations of Theca Cells with chemical compounds


Gene context of Theca Cells


Analytical, diagnostic and therapeutic context of Theca Cells


  1. Corticotropin-releasing hormone: a potent androgen secretagogue in girls with hyperandrogenism after precocious pubarche. Ibáñez, L., Potau, N., Marcos, M.V., de Zegher, F. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  2. Selective theca cell dysfunction in autoimmune oophoritis results in multifollicular development, decreased estradiol, and elevated inhibin B levels. Welt, C.K., Falorni, A., Taylor, A.E., Martin, K.A., Hall, J.E. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  3. Immunohistochemical studies of steroidogenic enzymes (aromatase, 17 alpha-hydroxylase and cholesterol side-chain cleavage cytochromes P-450) in sex cord-stromal tumors of the ovary. Sasano, H., Okamoto, M., Mason, J.I., Simpson, E.R., Mendelson, C.R., Sasano, N., Silverberg, S.G. Hum. Pathol. (1989) [Pubmed]
  4. Immunohistochemical and biochemical analysis of a human Sertoli-Leydig cell tumor: autonomous steroid production characteristic of ovarian theca cells. Sawetawan, C., Rainey, W.E., Word, R.A., Carr, B.R. J. Soc. Gynecol. Investig. (1995) [Pubmed]
  5. In-vitro ovarian steroidogenesis in women with pelvic congestion. Gilling-Smith, C., Mason, H., Willis, D., Franks, S., Beard, R.W. Hum. Reprod. (2000) [Pubmed]
  6. Hormonal regulation of ovarian cellular proliferation. Rao, M.C., Midgley, A.R., Richards, J.S. Cell (1978) [Pubmed]
  7. Human intraovarian interleukin-1 (IL-1) system: highly compartmentalized and hormonally dependent regulation of the genes encoding IL-1, its receptor, and its receptor antagonist. Hurwitz, A., Loukides, J., Ricciarelli, E., Botero, L., Katz, E., McAllister, J.M., Garcia, J.E., Rohan, R., Adashi, E.Y., Hernandez, E.R. J. Clin. Invest. (1992) [Pubmed]
  8. Molecular aspects of hormone action in ovarian follicular development, ovulation, and luteinization. Richards, J.S., Hedin, L. Annu. Rev. Physiol. (1988) [Pubmed]
  9. The molecular phenotype of polycystic ovary syndrome (PCOS) theca cells and new candidate PCOS genes defined by microarray analysis. Wood, J.R., Nelson, V.L., Ho, C., Jansen, E., Wang, C.Y., Urbanek, M., McAllister, J.M., Mosselman, S., Strauss, J.F. J. Biol. Chem. (2003) [Pubmed]
  10. Normal human ovary and ovarian tumors express glycodelin, a glycoprotein with immunosuppressive and contraceptive properties. Kämäräinen, M., Leivo, I., Koistinen, R., Julkunen, M., Karvonen, U., Rutanen, E.M., Seppälä, M. Am. J. Pathol. (1996) [Pubmed]
  11. Lysophosphatidic acid signals through mitogen-activated protein kinase-extracellular signal regulated kinase in ovarian theca cells expressing the LPA1/edg2-receptor: involvement of a nonclassical pathway? Budnik, L.T., Brunswig-Spickenheier, B., Mukhopadhyay, A.K. Mol. Endocrinol. (2003) [Pubmed]
  12. Molecular characterization of the follicle defects in the growth differentiation factor 9-deficient ovary. Elvin, J.A., Yan, C., Wang, P., Nishimori, K., Matzuk, M.M. Mol. Endocrinol. (1999) [Pubmed]
  13. Extracellular matrices of the avian ovarian follicle. Molecular characterization of chicken perlecan. Hummel, S., Osanger, A., Bajari, T.M., Balasubramani, M., Halfter, W., Nimpf, J., Schneider, W.J. J. Biol. Chem. (2004) [Pubmed]
  14. Differential expression of the angiogenic factor genes vascular endothelial growth factor (VEGF) and endocrine gland-derived VEGF in normal and polycystic human ovaries. Ferrara, N., Frantz, G., LeCouter, J., Dillard-Telm, L., Pham, T., Draksharapu, A., Giordano, T., Peale, F. Am. J. Pathol. (2003) [Pubmed]
  15. Gonadal autoantibodies in patients with hypogonadism and/or Addison's disease. Elder, M., Maclaren, N., Riley, W. J. Clin. Endocrinol. Metab. (1981) [Pubmed]
  16. Identification and cellular localization of growth hormone receptor gene expression in the human ovary. Sharara, F.I., Nieman, L.K. J. Clin. Endocrinol. Metab. (1994) [Pubmed]
  17. Augmented androgen production is a stable steroidogenic phenotype of propagated theca cells from polycystic ovaries. Nelson, V.L., Legro, R.S., Strauss, J.F., McAllister, J.M. Mol. Endocrinol. (1999) [Pubmed]
  18. Targeted disruption of the Insl3 gene causes bilateral cryptorchidism. Zimmermann, S., Steding, G., Emmen, J.M., Brinkmann, A.O., Nayernia, K., Holstein, A.F., Engel, W., Adham, I.M. Mol. Endocrinol. (1999) [Pubmed]
  19. Egr-1 induction in rat granulosa cells by follicle-stimulating hormone and luteinizing hormone: combinatorial regulation by transcription factors cyclic adenosine 3',5'-monophosphate regulatory element binding protein, serum response factor, sp1, and early growth response factor-1. Russell, D.L., Doyle, K.M., Gonzales-Robayna, I., Pipaon, C., Richards, J.S. Mol. Endocrinol. (2003) [Pubmed]
  20. Alterations in mitogen-activated protein kinase kinase and extracellular regulated kinase signaling in theca cells contribute to excessive androgen production in polycystic ovary syndrome. Nelson-Degrave, V.L., Wickenheisser, J.K., Hendricks, K.L., Asano, T., Fujishiro, M., Legro, R.S., Kimball, S.R., Strauss, J.F., McAllister, J.M. Mol. Endocrinol. (2005) [Pubmed]
  21. Increased transcription and increased messenger ribonucleic acid (mRNA) stability contribute to increased GATA6 mRNA abundance in polycystic ovary syndrome theca cells. Ho, C.K., Wood, J.R., Stewart, D.R., Ewens, K., Ankener, W., Wickenheisser, J., Nelson-Degrave, V., Zhang, Z., Legro, R.S., Dunaif, A., McAllister, J.M., Spielman, R., Strauss, J.F. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  22. Localization of renin gene expression to monkey ovarian theca cells by in situ hybridization. Itskovitz, J., Bruneval, P., Soubrier, F., Thaler, I., Corvol, P., Sealey, J.E. J. Clin. Endocrinol. Metab. (1992) [Pubmed]
  23. The biochemical basis for increased testosterone production in theca cells propagated from patients with polycystic ovary syndrome. Nelson, V.L., Qin Kn, K.N., Rosenfield, R.L., Wood, J.R., Penning, T.M., Legro, R.S., Strauss, J.F., McAllister, J.M. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  24. Ephrin B1 is expressed on human luteinizing granulosa cells in corpora lutea of the early luteal phase: the possible involvement of the B class Eph-ephrin system during corpus luteum formation. Egawa, M., Yoshioka, S., Higuchi, T., Sato, Y., Tatsumi, K., Fujiwara, H., Fujii, S. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
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