The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

FGF8  -  fibroblast growth factor 8 (androgen-induced)

Bos taurus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on FGF8

  • We have investigated the structural requirements for heparin/heparan sulfate in binding and activation of FGF8 (splice variant b) [1].
  • FGFR-4 was only observed when all follicle classes of an individual were expressing both FGF-8 and FGFR-3c [2].
  • Fgf8 expression was detected in oocytes and in granulosa and theca cells; this expression pattern differs from that reported in rodents [3].
  • RT-PCR was used to analyze bovine Fgf8, Fgfr3c and Fgfr4 mRNA levels in oocytes, and granulosa and theca cells [3].

Anatomical context of FGF8

  • FGF-8 and FGFR-3c were expressed in secondary follicles in 70% of fetuses examined, whereas FGFR-4 expression was significantly less frequent (20%) [2].

Other interactions of FGF8

  • In the present study, we tested the hypothesis that FGF-8 and its cognate receptors (FGFR3c and FGFR4) are expressed in bovine antral follicles [3].


  1. Heparin/Heparan sulfate domains in binding and signaling of fibroblast growth factor 8b. Loo, B.M., Salmivirta, M. J. Biol. Chem. (2002) [Pubmed]
  2. Expression of fibroblast growth factor-8 and its cognate receptors, fibroblast growth factor receptor (FGFR)-3c and-4, in fetal bovine preantral follicles. Buratini, J., Glapinski, V.F., Giometti, I.C., Teixeira, A.B., Costa, I.B., Avellar, M.C., Barros, C.M., Price, C.A. Mol. Reprod. Dev. (2005) [Pubmed]
  3. Expression of fibroblast growth factor-8 and regulation of cognate receptors, fibroblast growth factor receptor-3c and -4, in bovine antral follicles. Buratini, J., Teixeira, A.B., Costa, I.B., Glapinski, V.F., Pinto, M.G., Giometti, I.C., Barros, C.M., Cao, M., Nicola, E.S., Price, C.A. Reproduction (2005) [Pubmed]
WikiGenes - Universities