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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

FGF8  -  fibroblast growth factor 8 (androgen-induced)

Bos taurus

 
 
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High impact information on FGF8

  • We have investigated the structural requirements for heparin/heparan sulfate in binding and activation of FGF8 (splice variant b) [1].
  • FGFR-4 was only observed when all follicle classes of an individual were expressing both FGF-8 and FGFR-3c [2].
  • Fgf8 expression was detected in oocytes and in granulosa and theca cells; this expression pattern differs from that reported in rodents [3].
  • RT-PCR was used to analyze bovine Fgf8, Fgfr3c and Fgfr4 mRNA levels in oocytes, and granulosa and theca cells [3].
 

Anatomical context of FGF8

  • FGF-8 and FGFR-3c were expressed in secondary follicles in 70% of fetuses examined, whereas FGFR-4 expression was significantly less frequent (20%) [2].
 

Other interactions of FGF8

  • In the present study, we tested the hypothesis that FGF-8 and its cognate receptors (FGFR3c and FGFR4) are expressed in bovine antral follicles [3].

References

  1. Heparin/Heparan sulfate domains in binding and signaling of fibroblast growth factor 8b. Loo, B.M., Salmivirta, M. J. Biol. Chem. (2002) [Pubmed]
  2. Expression of fibroblast growth factor-8 and its cognate receptors, fibroblast growth factor receptor (FGFR)-3c and-4, in fetal bovine preantral follicles. Buratini, J., Glapinski, V.F., Giometti, I.C., Teixeira, A.B., Costa, I.B., Avellar, M.C., Barros, C.M., Price, C.A. Mol. Reprod. Dev. (2005) [Pubmed]
  3. Expression of fibroblast growth factor-8 and regulation of cognate receptors, fibroblast growth factor receptor-3c and -4, in bovine antral follicles. Buratini, J., Teixeira, A.B., Costa, I.B., Glapinski, V.F., Pinto, M.G., Giometti, I.C., Barros, C.M., Cao, M., Nicola, E.S., Price, C.A. Reproduction (2005) [Pubmed]
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