The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

MESTIT1  -  MEST intronic transcript 1, antisense RNA

Homo sapiens

Synonyms: MEST-AS1, MEST-IT, MEST-IT1, NCRNA00040, PEG1-AS
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on MESTIT1

  • Our results suggest that MESTIT1 is a paternally expressed non-coding RNA that may be involved in the regulation of MEST expression during development [1].
  • This DNA exhibited strong promoter activity in both the sense and antisense directions, indicating that PEG1-AS and P2 exon share a common promoter region [2].
  • Of interest, PEG1-AS was expressed predominantly in testis and in mature motile spermatozoa, indicating a possible role for this transcript in human sperm physiology and fertilization [2].
  • Firstly, a replication timing study across 7q32 showed that an extensive genomic region including the CPAs, MEST, MESTIT1, and COPG2IT1 replicates asynchronously [3].

Biological context of MESTIT1

  • Identification and characterization of an imprinted antisense RNA (MESTIT1) in the human MEST locus on chromosome 7q32 [1].

Analytical, diagnostic and therapeutic context of MESTIT1


  1. Identification and characterization of an imprinted antisense RNA (MESTIT1) in the human MEST locus on chromosome 7q32. Nakabayashi, K., Bentley, L., Hitchins, M.P., Mitsuya, K., Meguro, M., Minagawa, S., Bamforth, J.S., Stanier, P., Preece, M., Weksberg, R., Oshimura, M., Moore, G.E., Scherer, S.W. Hum. Mol. Genet. (2002) [Pubmed]
  2. An imprinted PEG1/MEST antisense expressed predominantly in human testis and in mature spermatozoa. Li, T., Vu, T.H., Lee, K.O., Yang, Y., Nguyen, C.V., Bui, H.Q., Zeng, Z.L., Nguyen, B.T., Hu, J.F., Murphy, S.K., Jirtle, R.L., Hoffman, A.R. J. Biol. Chem. (2002) [Pubmed]
  3. The imprinted region on human chromosome 7q32 extends to the carboxypeptidase A gene cluster: an imprinted candidate for Silver-Russell syndrome. Bentley, L., Nakabayashi, K., Monk, D., Beechey, C., Peters, J., Birjandi, Z., Khayat, F.E., Patel, M., Preece, M.A., Stanier, P., Scherer, S.W., Moore, G.E. J. Med. Genet. (2003) [Pubmed]
WikiGenes - Universities