Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

MESTIT1 - MEST intronic transcript 1, antisense RNA

Homo sapiens

Synonyms: MEST-AS1, MEST-IT, MEST-IT1, NCRNA00040, PEG1-AS

Nakabayashi, K. et al., Li, T. et al., Bentley, L. et al.

Bentley, Nakabayashi, Monk, Beechey, Peters, Birjandi, Khayat, Patel, Preece, Stanier, Scherer, Moore,

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High impact information on MESTIT1

Our results suggest that MESTIT1 is a paternally expressed non-coding RNA that may be involved in the regulation of MEST expression during development [1].
This DNA exhibited strong promoter activity in both the sense and antisense directions, indicating that PEG1-AS and P2 exon share a common promoter region [2].
Of interest, PEG1-AS was expressed predominantly in testis and in mature motile spermatozoa, indicating a possible role for this transcript in human sperm physiology and fertilization [2].
Firstly, a replication timing study across 7q32 showed that an extensive genomic region including the CPAs, MEST, MESTIT1, and COPG2IT1 replicates asynchronously [3].

Biological context of MESTIT1

Identification and characterization of an imprinted antisense RNA (MESTIT1) in the human MEST locus on chromosome 7q32 [1].

Analytical, diagnostic and therapeutic context of MESTIT1

PEG1-AS is a spliced transcript and was detected as a strong 2.4-kilobase band on a Northern blot [2].

References

Identification and characterization of an imprinted antisense RNA (MESTIT1) in the human MEST locus on chromosome 7q32. Nakabayashi, K., Bentley, L., Hitchins, M.P., Mitsuya, K., Meguro, M., Minagawa, S., Bamforth, J.S., Stanier, P., Preece, M., Weksberg, R., Oshimura, M., Moore, G.E., Scherer, S.W. Hum. Mol. Genet. (2002) [Pubmed]
An imprinted PEG1/MEST antisense expressed predominantly in human testis and in mature spermatozoa. Li, T., Vu, T.H., Lee, K.O., Yang, Y., Nguyen, C.V., Bui, H.Q., Zeng, Z.L., Nguyen, B.T., Hu, J.F., Murphy, S.K., Jirtle, R.L., Hoffman, A.R. J. Biol. Chem. (2002) [Pubmed]
The imprinted region on human chromosome 7q32 extends to the carboxypeptidase A gene cluster: an imprinted candidate for Silver-Russell syndrome. Bentley, L., Nakabayashi, K., Monk, D., Beechey, C., Peters, J., Birjandi, Z., Khayat, F.E., Patel, M., Preece, M.A., Stanier, P., Scherer, S.W., Moore, G.E. J. Med. Genet. (2003) [Pubmed]

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