Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

HNRNPAB - heterogeneous nuclear ribonucleoprotein A/B

Homo sapiens

Synonyms: ABBP-1, ABBP1, APOBEC1-binding protein 1, FLJ40338, HNRPAB, ...

Lau, P.P. et al., Fomenkov, A. et al., Cano, J.P. et al.

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High impact information on HNRPAB

Moreover the physical association of p63alpha and ABBP1 led to a specific shift of FGFR-2 alternative splicing toward the K-SAM isoform essential for epithelial differentiation [1].
Down-regulation of ABBP-1 in an apobec-1-expressing HepG2 cell line by transfection with an antisense ABBP-1 cDNA construct leads to inhibition of endogenous apoB mRNA editing [2].
Cloning of an Apobec-1-binding protein that also interacts with apolipoprotein B mRNA and evidence for its involvement in RNA editing [2].
After alkaline ether extraction the bromazepam and methylbromazepam obtained from sulfuric acid reextraction are hydrolyzed to ABBP and to MABBP, respectively [3].

Other interactions of HNRPAB

We used the yeast two-hybrid system to identify an apobec-1-interacting protein, ABBP-1 [2].

Analytical, diagnostic and therapeutic context of HNRPAB

Northern blot analysis indicates that ABBP-1 mRNA is distributed in multiple human tissues [2].

References

P63 alpha mutations lead to aberrant splicing of keratinocyte growth factor receptor in the Hay-Wells syndrome. Fomenkov, A., Huang, Y.P., Topaloglu, O., Brechman, A., Osada, M., Fomenkova, T., Yuriditsky, E., Trink, B., Sidransky, D., Ratovitski, E. J. Biol. Chem. (2003) [Pubmed]
Cloning of an Apobec-1-binding protein that also interacts with apolipoprotein B mRNA and evidence for its involvement in RNA editing. Lau, P.P., Zhu, H.J., Nakamuta, M., Chan, L. J. Biol. Chem. (1997) [Pubmed]
Determination of bromazepam in plasma with an internal standard by gas-liquid chromatography. Cano, J.P., Baille, A.M., Viala, A. Arzneimittel-Forschung. (1975) [Pubmed]

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HNRNPAB	Bos taurus
hnrnpabb	Danio rerio
hnrnpaba	Danio rerio
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