Gene Review:
FGFR2 - fibroblast growth factor receptor 2
Homo sapiens
Synonyms:
BBDS, BEK, BFR-1, CD332, CEK3, ...
Tang,
Frisén,
Lundberg,
Halliger-Keller,
Beleza-Meireles,
Mao,
Wiedlocha,
Evans,
Robson,
Heer,
Haugsten,
Collins,
Wu,
Kress,
Shen,
Zhao,
Sørensen,
Zhang,
Lagerstedt,
Shenton,
Hayward,
Cao,
Chan,
Olsnes,
Leung,
Mueller,
Britto,
Jones,
Wesche,
Nordenskjöld,
Collmann,
Dai,
Wang,
Sun,
Mei,
Khnykin,
Büsse,
Zhou,
Omrani,
- Fibroblast growth factor receptor 3 (FGFR3) transmembrane mutation in Crouzon syndrome with acanthosis nigricans. Meyers, G.A., Orlow, S.J., Munro, I.R., Przylepa, K.A., Jabs, E.W. Nat. Genet. (1995)
- Biochemical analysis of pathogenic ligand-dependent FGFR2 mutations suggests distinct pathophysiological mechanisms for craniofacial and limb abnormalities. Ibrahimi, O.A., Zhang, F., Eliseenkova, A.V., Itoh, N., Linhardt, R.J., Mohammadi, M. Hum. Mol. Genet. (2004)
- Analysis of the mutational spectrum of the FGFR2 gene in Pfeiffer syndrome. Cornejo-Roldan, L.R., Roessler, E., Muenke, M. Hum. Genet. (1999)
- Evaluation of the fibroblast growth factor system as a potential target for therapy in human prostate cancer. Gowardhan, B., Douglas, D.A., Mathers, M.E., McKie, A.B., McCracken, S.R., Robson, C.N., Leung, H.Y. Br. J. Cancer (2005)
- Identical mutations in three different fibroblast growth factor receptor genes in autosomal dominant craniosynostosis syndromes. Bellus, G.A., Gaudenz, K., Zackai, E.H., Clarke, L.A., Szabo, J., Francomano, C.A., Muenke, M. Nat. Genet. (1996)
- Exclusive paternal origin of new mutations in Apert syndrome. Moloney, D.M., Slaney, S.F., Oldridge, M., Wall, S.A., Sahlin, P., Stenman, G., Wilkie, A.O. Nat. Genet. (1996)
- FGFR2 mutations in Pfeiffer syndrome. Lajeunie, E., Ma, H.W., Bonaventure, J., Munnich, A., Le Merrer, M., Renier, D. Nat. Genet. (1995)
- Identical mutations in the FGFR2 gene cause both Pfeiffer and Crouzon syndrome phenotypes. Rutland, P., Pulleyn, L.J., Reardon, W., Baraitser, M., Hayward, R., Jones, B., Malcolm, S., Winter, R.M., Oldridge, M., Slaney, S.F. Nat. Genet. (1995)
- Differential signal transduction of alternatively spliced FGFR2 variants expressed in human mammary epithelial cells. Moffa, A.B., Ethier, S.P. J. Cell. Physiol. (2007)
- Trp290Cys mutation in exon IIIa of the fibroblast growth factor receptor 2 (FGFR2) gene is associated with Pfeiffer syndrome. Tartaglia, M., Valeri, S., Velardi, F., Di Rocco, C., Battaglia, P.A. Hum. Genet. (1997)
- A soluble form of K-sam/FGFR2 protein in the culture medium of human gastric cancer cells. Kishi, T., Yoshida, T., Terada, M. Biochem. Biophys. Res. Commun. (1994)
- A Novel Molecular Targeting Compound as K-samII/FGF-R2 Phosphorylation Inhibitor, Ki23057, for Scirrhous Gastric Cancer. Nakamura, K., Yashiro, M., Matsuoka, T., Tendo, M., Shimizu, T., Miwa, A., Hirakawa, K. Gastroenterology (2006)
- Estrogen receptor-associated expression of keratinocyte growth factor and its possible role in the inhibition of apoptosis in human breast cancer. Tamaru, N., Hishikawa, Y., Ejima, K., Nagasue, N., Inoue, S., Muramatsu, M., Hayashi, T., Koji, T. Lab. Invest. (2004)
- Genomic screening of fibroblast growth-factor receptor 2 reveals a wide spectrum of mutations in patients with syndromic craniosynostosis. Kan, S.H., Elanko, N., Johnson, D., Cornejo-Roldan, L., Cook, J., Reich, E.W., Tomkins, S., Verloes, A., Twigg, S.R., Rannan-Eliya, S., McDonald-McGinn, D.M., Zackai, E.H., Wall, S.A., Muenke, M., Wilkie, A.O. Am. J. Hum. Genet. (2002)
- Cellular signaling by fibroblast growth factor receptors. Eswarakumar, V.P., Lax, I., Schlessinger, J. Cytokine Growth Factor Rev. (2005)
- Different abilities of the four FGFRs to mediate FGF-1 translocation are linked to differences in the receptor C-terminal tail. S??rensen, V., Wiedlocha, A., Haugsten, E.M., Khnykin, D., Wesche, J., Olsnes, S. J. Cell. Sci. (2006)
- KGF suppresses alpha2beta1 integrin function and promotes differentiation of the transient amplifying population in human prostatic epithelium. Heer, R., Collins, A.T., Robson, C.N., Shenton, B.K., Leung, H.Y. J. Cell. Sci. (2006)
- FGF7/KGF triggers cell transformation and invasion on immortalised human prostatic epithelial PNT1A cells. Ropiquet, F., Huguenin, S., Villette, J.M., Ronflé, V., Le Brun, G., Maitland, N.J., Cussenot, O., Fiet, J., Berthon, P. Int. J. Cancer (1999)
- P253R fibroblast growth factor receptor-2 mutation induces RUNX2 transcript variants and calvarial osteoblast differentiation. Baroni, T., Carinci, P., Lilli, C., Bellucci, C., Aisa, M.C., Scapoli, L., Volinia, S., Carinci, F., Pezzetti, F., Calvitti, M., Farina, A., Conte, C., Bodo, M. J. Cell. Physiol. (2005)
- Expression of basic fibroblast growth factor in squamous cell carcinoma of the head and neck is associated with degree of histologic differentiation. Janot, F., el-Naggar, A.K., Morrison, R.S., Liu, T.J., Taylor, D.L., Clayman, G.L. Int. J. Cancer (1995)
- Localisation and differential expression of the fibroblast growth factor receptor (FGFR) multigene family in normal and atherosclerotic human arteries. Hughes, S.E. Cardiovasc. Res. (1996)
- Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin. Pellegrini, L., Burke, D.F., von Delft, F., Mulloy, B., Blundell, T.L. Nature (2000)
- Clustering of FGFR2 gene mutations inpatients with Pfeiffer and Crouzon syndromes (FGFR2-associated craniosynostoses). Kress, W., Collmann, H., Büsse, M., Halliger-Keller, B., Mueller, C.R. Cytogenet. Cell Genet. (2000)
- Transforming potential of alternatively spliced variants of fibroblast growth factor receptor 2 in human mammary epithelial cells. Moffa, A.B., Tannheimer, S.L., Ethier, S.P. Mol. Cancer Res. (2004)
- Effect of keratinocyte growth factor on cell viability in primary cultured human prostate cancer stromal cells. Huang, Y.W., Wang, L.S., Chang, H.L., Ye, W., Shu, S., Sugimoto, Y., Lin, Y.C. J. Steroid Biochem. Mol. Biol. (2006)
- The cytoplasmic tyrosine kinase Pyk2 as a novel effector of fibroblast growth factor receptor 3 activation. Meyer, A.N., Gastwirt, R.F., Schlaepfer, D.D., Donoghue, D.J. J. Biol. Chem. (2004)
- A role for fibroblast growth factor receptor-2 in the altered osteoblast phenotype induced by Twist haploinsufficiency in the Saethre-Chotzen syndrome. Guenou, H., Kaabeche, K., Mée, S.L., Marie, P.J. Hum. Mol. Genet. (2005)
- Heparin differentially regulates the interaction of fibroblast growth factor-4 with FGF receptors 1 and 2. Aviezer, D., Safran, M., Yayon, A. Biochem. Biophys. Res. Commun. (1999)
- Keratinocyte growth factor receptor expression in normal colorectal epithelial cells and differentiated type of colorectal cancer. Yoshino, M., Ishiwata, T., Watanabe, M., Komine, O., Shibuya, T., Tokunaga, A., Naito, Z. Oncol. Rep. (2005)
- Structural basis by which alternative splicing confers specificity in fibroblast growth factor receptors. Yeh, B.K., Igarashi, M., Eliseenkova, A.V., Plotnikov, A.N., Sher, I., Ron, D., Aaronson, S.A., Mohammadi, M. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Fibroblast growth factors and their receptors in parathyroid disease. Lambert, D., Eaton, C.L., Harrison, B.J. World journal of surgery. (1998)
- Role of keratinocyte growth factor in the pathogenesis of autosomal dominant polycystic kidney disease. Mei, C., Mao, Z., Shen, X., Wang, W., Dai, B., Tang, B., Wu, Y., Cao, Y., Zhang, S., Zhao, H., Sun, T. Nephrol. Dial. Transplant. (2005)
- Cbl-mediated ubiquitination of alpha5 integrin subunit mediates fibronectin-dependent osteoblast detachment and apoptosis induced by FGFR2 activation. Kaabeche, K., Guenou, H., Bouvard, D., Didelot, N., Listrat, A., Marie, P.J. J. Cell. Sci. (2005)
- Structural interactions of fibroblast growth factor receptor with its ligands. Stauber, D.J., DiGabriele, A.D., Hendrickson, W.A. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Identification of a novel variant form of fibroblast growth factor receptor 3 (FGFR3 IIIb) in human colonic epithelium. Murgue, B., Tsunekawa, S., Rosenberg, I., deBeaumont, M., Podolsky, D.K. Cancer Res. (1994)
- Expression of FGF and FGF receptor genes in human breast cancer. Penault-Llorca, F., Bertucci, F., Adélaïde, J., Parc, P., Coulier, F., Jacquemier, J., Birnbaum, D., deLapeyrière, O. Int. J. Cancer (1995)
- FGFR2, FGF8, FGF10 and BMP7 as candidate genes for hypospadias. Beleza-Meireles, A., Lundberg, F., Lagerstedt, K., Zhou, X., Omrani, D., Frisén, L., Nordenskjöld, A. Eur. J. Hum. Genet. (2007)
- Molecular basis of congenital hypopigmentary disorders in humans: a review. Boissy, R.E., Nordlund, J.J. Pigment Cell Res. (1997)
- Epigenetically controlled fibroblast growth factor receptor 2 signaling imposes on the RAS/BRAF/mitogen-activated protein kinase pathway to modulate thyroid cancer progression. Kondo, T., Zheng, L., Liu, W., Kurebayashi, J., Asa, S.L., Ezzat, S. Cancer Res. (2007)
- Expression of basic fibroblast growth factor and its receptors FGFR1 and FGFR2 in human benign prostatic hyperplasia treated with finasteride. Sáez, C., González-Baena, A.C., Japón, M.A., Giráldez, J., Segura, D.I., Rodríguez-Vallejo, J.M., González-Esteban, J., Miranda, G., Torrubia, F. Prostate (1999)
- Expression of basic fibroblast growth factor (bFGF), FGF receptor 1 and FGF receptor 2 in uterine leiomyomas and myometrium during the menstrual cycle, after menopause and GnRHa treatment. Wu, X., Blanck, A., Olovsson, M., Möller, B., Lindblom, B. Acta obstetricia et gynecologica Scandinavica. (2001)
- Differential expression of fibroblast growth factor receptors in human digital development suggests common pathogenesis in complex acrosyndactyly and craniosynostosis. Britto, J.A., Chan, J.C., Evans, R.D., Hayward, R.D., Jones, B.M. Plast. Reconstr. Surg. (2001)
- p21-activated protein kinase 4 (PAK4) interacts with the keratinocyte growth factor receptor and participates in keratinocyte growth factor-mediated inhibition of oxidant-induced cell death. Lu, Y., Pan, Z.Z., Devaux, Y., Ray, P. J. Biol. Chem. (2003)