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Gene Review

HP1b  -  Heterochromatin Protein 1b

Drosophila melanogaster

Synonyms: CG7041, Dmel\CG7041, HP1, HP1B, Hp1b
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Disease relevance of HP1b

  • Human HP1 was expressed as a GST-fusion in Escherichia coli and purified with glutathione-Sepharose [1].

High impact information on HP1b


Biological context of HP1b

  • Drosophila HP1 has been shown to be involved in position effect variegation and to be required for the correct chromosome segregation in vivo, while the biological activity of human homolog (HP1Hsa) has not yet been characterized [1].

Analytical, diagnostic and therapeutic context of HP1b

  • The DNA-binding activity of the recombinant HP1 was demonstrated by gel mobility shift assay and South-Western-type blotting [1].


  1. Human homolog of Drosophila heterochromatin-associated protein 1 (HP1) is a DNA-binding protein which possesses a DNA-binding motif with weak similarity to that of human centromere protein C (CENP-C). Sugimoto, K., Yamada, T., Muro, Y., Himeno, M. J. Biochem. (1996) [Pubmed]
  2. JAK signaling globally counteracts heterochromatic gene silencing. Shi, S., Calhoun, H.C., Xia, F., Li, J., Le, L., Li, W.X. Nat. Genet. (2006) [Pubmed]
  3. Cloning and expression of Drosophila HP1 homologs from a mealybug, Planococcus citri. Epstein, H., James, T.C., Singh, P.B. J. Cell. Sci. (1992) [Pubmed]
  4. The Heterochromatin Protein 1 family. Lomberk, G., Wallrath, L., Urrutia, R. Genome Biol. (2006) [Pubmed]
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