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MeSH Review

Histone Code

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High impact information on Histone Code


Biological context of Histone Code

  • Our results suggest a model in which H3K9 methylation by KYP, and H3K27 methylation by an unknown enzyme provide a combinatorial histone code for the recruitment of CMT3 to silent loci [6].
  • Lysine acetylation is one of several histone modifications that have been proposed to form the basis for a mechanism for recording epigenetically stable marks in chromatin, known as the histone code [7].
  • But, thanks to its prime positioning, a variation in the tail of H2AX enables rapid modification of the histone code in response to DNA damage [8].

Associations of Histone Code with chemical compounds


Gene context of Histone Code


  1. Deciphering the transcriptional histone acetylation code for a human gene. Agalioti, T., Chen, G., Thanos, D. Cell (2002) [Pubmed]
  2. Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly. Nakayama , J., Rice, J.C., Strahl, B.D., Allis, C.D., Grewal, S.I. Science (2001) [Pubmed]
  3. A histone code in meiosis: the histone kinase, NHK-1, is required for proper chromosomal architecture in Drosophila oocytes. Ivanovska, I., Khandan, T., Ito, T., Orr-Weaver, T.L. Genes Dev. (2005) [Pubmed]
  4. Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo. Aihara, H., Nakagawa, T., Yasui, K., Ohta, T., Hirose, S., Dhomae, N., Takio, K., Kaneko, M., Takeshima, Y., Muramatsu, M., Ito, T. Genes Dev. (2004) [Pubmed]
  5. Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27. Min, J., Zhang, Y., Xu, R.M. Genes Dev. (2003) [Pubmed]
  6. Dual histone H3 methylation marks at lysines 9 and 27 required for interaction with CHROMOMETHYLASE3. Lindroth, A.M., Shultis, D., Jasencakova, Z., Fuchs, J., Johnson, L., Schubert, D., Patnaik, D., Pradhan, S., Goodrich, J., Schubert, I., Jenuwein, T., Khorasanizadeh, S., Jacobsen, S.E. EMBO J. (2004) [Pubmed]
  7. Nucleosome binding by the bromodomain and PHD finger of the transcriptional cofactor p300. Ragvin, A., Valvatne, H., Erdal, S., Arskog, V., Tufteland, K.R., Breen, K., ØYan, A.M., Eberharter, A., Gibson, T.J., Becker, P.B., Aasland, R. J. Mol. Biol. (2004) [Pubmed]
  8. H2AX: the histone guardian of the genome. Fernandez-Capetillo, O., Lee, A., Nussenzweig, M., Nussenzweig, A. DNA Repair (Amst.) (2004) [Pubmed]
  9. Epigenetic theories of cancer initiation. Jaffe, L.F. Adv. Cancer Res. (2003) [Pubmed]
  10. A Trans-tail Histone Code Defined by Monomethylated H4 Lys-20 and H3 Lys-9 Demarcates Distinct Regions of Silent Chromatin. Sims, J.K., Houston, S.I., Magazinnik, T., Rice, J.C. J. Biol. Chem. (2006) [Pubmed]
  11. Vitamin A status in mice affects the histone code of the phosphoenolpyruvate carboxykinase gene in liver. Scribner, K.B., Odom, D.P., McGrane, M.M. J. Nutr. (2005) [Pubmed]
  12. X box-like sequences in the MHC class II region maintain regulatory function. Gomez, J.A., Majumder, P., Nagarajan, U.M., Boss, J.M. J. Immunol. (2005) [Pubmed]
  13. The histone code regulating expression of the imprinted mouse Igf2r gene. Yang, Y., Li, T., Vu, T.H., Ulaner, G.A., Hu, J.F., Hoffman, A.R. Endocrinology (2003) [Pubmed]
  14. A SANT motif in the SMRT corepressor interprets the histone code and promotes histone deacetylation. Yu, J., Li, Y., Ishizuka, T., Guenther, M.G., Lazar, M.A. EMBO J. (2003) [Pubmed]
  15. Histone acetylation-independent effect of histone deacetylase inhibitors on Akt through the reshuffling of protein phosphatase 1 complexes. Chen, C.S., Weng, S.C., Tseng, P.H., Lin, H.P., Chen, C.S. J. Biol. Chem. (2005) [Pubmed]
  16. Evidence for the existence of an HP1-mediated subcode within the histone code. Lomberk, G., Bensi, D., Fernandez-Zapico, M.E., Urrutia, R. Nat. Cell Biol. (2006) [Pubmed]
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