Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

Z - zinc finger protein

Mopeia Lassa virus reassortant 29

Strecker, T. et al., Strecker, T. et al., Eichler, R. et al., Perez, M. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Z

Lassa virus Z protein is a matrix protein and sufficient for the release of virus-like particles [corrected] [1].
Myristoylation of the RING finger Z protein is essential for arenavirus budding [2].

High impact information on Z

It contains an RNA ambisense genome that encodes the glycoprotein precursor GP-C, the nucleoprotein NP, the polymerase L, and the Z protein [1].
In this study, we examined particles secreted into the supernatant of a stably Z protein-expressing CHO cell line by electron microscopy [3].
We show that disruption of the N-terminal myristoylation signal by substituting the N-terminal glycine with alanine (Z-G2A mutant) resulted in a significant reduction of Z protein association with cellular membranes [4].

References

Lassa virus Z protein is a matrix protein and sufficient for the release of virus-like particles [corrected]. Strecker, T., Eichler, R., Meulen, J., Weissenhorn, W., Dieter Klenk, H., Garten, W., Lenz, O. J. Virol. (2003) [Pubmed]
Myristoylation of the RING finger Z protein is essential for arenavirus budding. Perez, M., Greenwald, D.L., de la Torre, J.C. J. Virol. (2004) [Pubmed]
Characterization of the Lassa virus matrix protein Z: electron microscopic study of virus-like particles and interaction with the nucleoprotein (NP). Eichler, R., Strecker, T., Kolesnikova, L., ter Meulen, J., Weissenhorn, W., Becker, S., Klenk, H.D., Garten, W., Lenz, O. Virus Res. (2004) [Pubmed]
The role of myristoylation in the membrane association of the Lassa virus matrix protein Z. Strecker, T., Maisa, A., Daffis, S., Eichler, R., Lenz, O., Garten, W. Virol. J. (2006) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.