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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Arenavirus

  • Here we report that lymphocytic choriomeningitis virus, the prototype arenavirus, is extremely susceptible to extinction mutagenesis by the base analog 5-fluorouracil [1].
  • A crucial role of the LARGE-dependent glycosylation of alpha-DG for virus binding is found for several isolates of LCMV, LFV, and the arenaviruses Mobala and Oliveros [2].
  • As reported herein, this requirement appears to be broadly applicable to the arenaviruses as determined by more extensive analysis of alpha-DG receptor usage and GP1 sequences of Old and New World arenaviruses [3].
  • Tamiami virus, a member of the arenavirus group, produces an acute CNS disease in suckling mice manifested primarily by cerebellar ataxia, paralysis, convulsions, and death [4].
  • These results strongly suggest that CCHF viruses (and other members of the genus Nairovirus) likely utilize the subtilase SKI-1/S1P-like cellular proteases for the major glycoprotein precursor cleavage events, as has recently been demonstrated for the arenaviruses [5].

High impact information on Arenavirus


Chemical compound and disease context of Arenavirus

  • In contrast to the classical view that signal peptides act primarily in targeting nascent polypeptides to the endoplasmic reticulum, we suggest that the signal peptide of the arenavirus GP-C may serve additional functions in envelope glycoprotein structure and trafficking [10].
  • All known arenavirus Z proteins contain a glycine (G) at position 2, which is a potential acceptor site for a myristoyl moiety [11].
  • The yields of Pichinde virus, a member of the arenavirus group, were markedly inhibited when infected BHK 21 cells were incubated in the presence of 0.4 to 4 mug/ml of actinomycin D [12].
  • Arenavirus inactivation on contact with N-substituted isatin beta-thiosemicarbazones and certain cations [13].
  • Polyacrylamide gel electrophoretic analysis of RNA segments of the arenaviruses Pichinde (Pic) and Tacaribe (Tac) showed them to be distinguishable in that Pic S RNA had a slower electrophoretic mobility than Tac S RNA [14].

Biological context of Arenavirus

  • Passage of the prototypic arenavirus lymphocytic choriomenigitis virus (LCMV) in cultured cells in the presence of the mutagenic agent 5-fluorouracil (FU) resulted in efficient and systematic virus extinction under conditions that did not significantly affect cell survival [15].
  • They are included in the Category A Pathogen List established by the Center for Disease Control and Prevention that groups agents with the greatest potential for adverse public health impact and mass casualties whether a situation characterized by a ill-intentioned abuse of natural or engineered arenavirus would be encountered [16].

Anatomical context of Arenavirus


Gene context of Arenavirus


Analytical, diagnostic and therapeutic context of Arenavirus


  1. Molecular indetermination in the transition to error catastrophe: systematic elimination of lymphocytic choriomeningitis virus through mutagenesis does not correlate linearly with large increases in mutant spectrum complexity. Grande-Pérez, A., Sierra, S., Castro, M.G., Domingo, E., Lowenstein, P.R. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  2. Posttranslational modification of alpha-dystroglycan, the cellular receptor for arenaviruses, by the glycosyltransferase LARGE is critical for virus binding. Kunz, S., Rojek, J.M., Kanagawa, M., Spiropoulou, C.F., Barresi, R., Campbell, K.P., Oldstone, M.B. J. Virol. (2005) [Pubmed]
  3. New World arenavirus clade C, but not clade A and B viruses, utilizes alpha-dystroglycan as its major receptor. Spiropoulou, C.F., Kunz, S., Rollin, P.E., Campbell, K.P., Oldstone, M.B. J. Virol. (2002) [Pubmed]
  4. The effect of neonatal thymectomy on Tamiami virus-induced central nervous system disease. Friedman, H.M., Gilden, D.H., Roosa, R.A., Nathanson, N. J. Neuropathol. Exp. Neurol. (1975) [Pubmed]
  5. Characterization of the glycoproteins of Crimean-Congo hemorrhagic fever virus. Sanchez, A.J., Vincent, M.J., Nichol, S.T. J. Virol. (2002) [Pubmed]
  6. Recovery of an arenavirus entirely from RNA polymerase I/II-driven cDNA. Flatz, L., Bergthaler, A., de la Torre, J.C., Pinschewer, D.D. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  7. Nucleocapsid protein gene of Junin arenavirus (cDNA sequence). Ghiringhelli, P.D., Rivera Pomar, R.V., Baro, N.I., Rosas, M.F., Grau, O., Romanowski, V. Nucleic Acids Res. (1989) [Pubmed]
  8. O Mannosylation of alpha-dystroglycan is essential for lymphocytic choriomeningitis virus receptor function. Imperiali, M., Thoma, C., Pavoni, E., Brancaccio, A., Callewaert, N., Oxenius, A. J. Virol. (2005) [Pubmed]
  9. Genetic and biochemical evidence for an oligomeric structure of the functional L polymerase of the prototypic arenavirus lymphocytic choriomeningitis virus. Sánchez, A.B., de la Torre, J.C. J. Virol. (2005) [Pubmed]
  10. The signal peptide of the Junín arenavirus envelope glycoprotein is myristoylated and forms an essential subunit of the mature G1-G2 complex. York, J., Romanowski, V., Lu, M., Nunberg, J.H. J. Virol. (2004) [Pubmed]
  11. Myristoylation of the RING finger Z protein is essential for arenavirus budding. Perez, M., Greenwald, D.L., de la Torre, J.C. J. Virol. (2004) [Pubmed]
  12. Inhibition of Pichinde virus replication by actinomycin D. Rawls, W.E., Banerjee, S.N., McMillan, C.A., Buchmeier, M.J. J. Gen. Virol. (1976) [Pubmed]
  13. Arenavirus inactivation on contact with N-substituted isatin beta-thiosemicarbazones and certain cations. Logan, J.C., Fox, M.P., Morgan, J.H., Makohon, A.M., Pfau, C.J. J. Gen. Virol. (1975) [Pubmed]
  14. Oligonucleotide fingerprint analysis of Tacaribe virion RNA. Gimenez, H.B., Compans, R.W. J. Gen. Virol. (1981) [Pubmed]
  15. Lethal mutagenesis of the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV). Ruiz-Jarabo, C.M., Ly, C., Domingo, E., de la Torre, J.C. Virology (2003) [Pubmed]
  16. Arenaviruses other than Lassa virus. Charrel, R.N., de Lamballerie, X. Antiviral Res. (2003) [Pubmed]
  17. Old and New World arenaviruses share a highly conserved epitope in the fusion domain of the glycoprotein 2, which is recognized by Lassa virus-specific human CD4+ T-cell clones. Meulen, J., Badusche, M., Satoguina, J., Strecker, T., Lenz, O., Loeliger, C., Sakho, M., Koulemou, K., Koivogui, L., Hoerauf, A. Virology (2004) [Pubmed]
  18. Murine immune responses to mucosally delivered Salmonella expressing Lassa fever virus nucleoprotein. Djavani, M., Yin, C., Xia, L., Lukashevich, I.S., Pauza, C.D., Salvato, M.S. Vaccine (2000) [Pubmed]
  19. Selective inhibition of arthropod-borne and arenaviruses in vitro by 3'-fluoro-3'-deoxyadenosine. Smee, D.F., Morris, J.L., Barnard, D.L., Van Aerschot, A. Antiviral Res. (1992) [Pubmed]
  20. Experimental reproduction of a spiking mortality syndrome of turkeys. Davis, J.F., McMurtry, J.P., Vasilatos-Younken, R., Connolly, B.M., Woolcock, P.R., Dunn, P.A. Avian Dis. (1997) [Pubmed]
  21. The lymphocytic choriomeningitis virus RING protein Z associates with eukaryotic initiation factor 4E and selectively represses translation in a RING-dependent manner. Campbell Dwyer, E.J., Lai, H., MacDonald, R.C., Salvato, M.S., Borden, K.L. J. Virol. (2000) [Pubmed]
  22. The RING domains of the promyelocytic leukemia protein PML and the arenaviral protein Z repress translation by directly inhibiting translation initiation factor eIF4E. Kentsis, A., Dwyer, E.C., Perez, J.M., Sharma, M., Chen, A., Pan, Z.Q., Borden, K.L. J. Mol. Biol. (2001) [Pubmed]
  23. Nucleotide sequence of the Lassa virus (Josiah strain) S genome RNA and amino acid sequence comparison of the N and GPC proteins to other arenaviruses. Auperin, D.D., McCormick, J.B. Virology (1989) [Pubmed]
  24. Standardization of a plaque assay for Lassa virus. Tomori, O., Johnson, K.M., Kiley, M.P., Elliott, L.H. J. Med. Virol. (1987) [Pubmed]
  25. Cells expressing the RING finger Z protein are resistant to arenavirus infection. Cornu, T.I., Feldmann, H., de la Torre, J.C. J. Virol. (2004) [Pubmed]
  26. Antiviral effect of ribavirin on Junin virus replication in vitro. Rodríguez, M., McCormick, J.B., Weissenbacher, M.C. Rev. Argent. Microbiol. (1986) [Pubmed]
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