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Gene Review

crtL  -  lycopene cyclase

Synechococcus elongatus PCC 6301

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Disease relevance of crtL


High impact information on crtL


Chemical compound and disease context of crtL


Associations of crtL with chemical compounds

  • We have cloned a cyanobacterial gene encoding lycopene cyclase, an enzyme that converts the acyclic carotenoid lycopene to the bicyclic molecule beta-carotene [2].
  • When the subsequent genes from E. uredovora which encode for lycopene cyclase and beta-carotene hydroxylase were present, neurosporene, the phytoene desaturase product of R. capsulatus, was subsequently converted to the monocyclic beta-zeacarotene and its monohydroxylation product [3].


  1. Molecular structure and enzymatic function of lycopene cyclase from the cyanobacterium Synechococcus sp strain PCC7942. Cunningham, F.X., Sun, Z., Chamovitz, D., Hirschberg, J., Gantt, E. Plant Cell (1994) [Pubmed]
  2. Cloning and functional expression in Escherichia coli of a cyanobacterial gene for lycopene cyclase, the enzyme that catalyzes the biosynthesis of beta-carotene. Cunningham, F.X., Chamovitz, D., Misawa, N., Gantt, E., Hirschberg, J. FEBS Lett. (1993) [Pubmed]
  3. Functional complementation in Escherichia coli of different phytoene desaturase genes and analysis of accumulated carotenes. Linden, H., Misawa, N., Chamovitz, D., Pecker, I., Hirschberg, J., Sandmann, G. Z. Naturforsch., C, J. Biosci. (1991) [Pubmed]
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