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Gene Review:

whiB7 - transcriptional regulator WhiB7

Mycobacterium tuberculosis H37Rv

Morris, R.P. et al., Geiman, D.E. et al.

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Disease relevance of whiB7

In addition to antibiotics, whiB7 is induced by exposure to fatty acids that pathogenic Mycobacterium species may accumulate internally or encounter within eukaryotic hosts during infection [1].
This system depends on whiB7, a gene that pathogenic Mycobacterium shares with Streptomyces, a phylogenetically related genus known as the source of diverse antibiotics [1].
This information together with biochemical analyses of the whiB1 to whiB7 gene products will be important for understanding the biology of this novel family of proteins in mycobacteria and related actinomycetes [2].

High impact information on whiB7

In M. tuberculosis, whiB7 is induced by subinhibitory concentrations of antibiotics (erythromycin, tetracycline, and streptomycin) and whiB7 null mutants (Streptomyces and Mycobacterium) are hypersusceptible to antibiotics in vitro [1].

References

Ancestral antibiotic resistance in Mycobacterium tuberculosis. Morris, R.P., Nguyen, L., Gatfield, J., Visconti, K., Nguyen, K., Schnappinger, D., Ehrt, S., Liu, Y., Heifets, L., Pieters, J., Schoolnik, G., Thompson, C.J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
Differential gene expression in response to exposure to antimycobacterial agents and other stress conditions among seven Mycobacterium tuberculosis whiB-like genes. Geiman, D.E., Raghunand, T.R., Agarwal, N., Bishai, W.R. Antimicrob. Agents Chemother. (2006) [Pubmed]

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