Gene Review:
cpox - coproporphyrinogen oxidase
Danio rerio
Synonyms:
SO:0000704, cb535, cpo, sb:cb535, wu:fc43a01
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Disease relevance of cpox
- Injection of human CPO RNA, but not a mutant CPO RNA that is similar to a mutant responsible for a hereditary coproporphyria (HCP), restores hemoglobin production in the CPO-MO-injected embryos [1].
High impact information on cpox
- In contrast, over-expression of biklf and gata1 significantly induces ectopic CPO expression [1].
- Knockdown of zebrafish CPO using anti-sense morpholinos (CPO-MO) leads to a significant suppression of hemoglobin production without apparent reduction of blood cells [1].
- We found that the sixth heme synthesis enzyme, coproporphyrinogen oxidase (CPO), is predominantly expressed in the intermediate cell mass (ICM) that is a major site of zebrafish primitive hematopoiesis [1].
Regulatory relationships of cpox
- Furthermore, expression of CPO in the ICM is severely suppressed in both vlad tepes/gata1 mutants and in biklf-MO-injected embryos [1].
References
- Characterization of the heme synthesis enzyme coproporphyrinogen oxidase (CPO) in zebrafish erythrogenesis. Hanaoka, R., Katayama, S., Dawid, I.B., Kawahara, A. Genes Cells (2006) [Pubmed]
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