Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Lsp1alpha - Larval serum protein 1 alpha

Drosophila melanogaster

Synonyms: CG2559, DmeLSP1a, Dmel\CG2559, Hexamerin-1-alpha, LSP 1, ...

Ghosh, S. et al., Ghosh, S. et al., Deutsch, J. et al., Roberts, D.B. et al., Lazareva, A.A. et al.

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High impact information on Lsp1alpha

The LSP1-alpha gene of Drosophila melanogaster is located on the X chromosome at 11B yet is not dosage compensated [1].
The genetic and cytogenetic localization of the three structural genes coding for the major protein of drosophila larval serum [2].
The Pl gene, together with the LSP-1 alpha, -1 beta, and -1 gamma, LSP-2, and P6 genes, is expressed exclusively in the larval fat body of D. melanogaster during the third instar [3].
The X-linked gene LSP1-alpha of Drosophila melanogaster, expressed in the third larval instar, does not exhibit dosage compensation at its normal locus but does compensate when it is relocated to ectopic sites on the X chromosome [4].
To test its role in male courtship, fat body was feminized using the highly specific Larval serum protein promoter [5].

Biological context of Lsp1alpha

Our results show that the LSP1-alpha gene exhibits equivalent levels of transcripts in the two sexes when it is relocated to either an autosomal site or to an ectopic site on the X chromosome [1].

References

The LSP1-alpha gene of Drosophila melanogaster exhibits dosage compensation when it is relocated to a different site on the X chromosome. Ghosh, S., Chatterjee, R.N., Bunick, D., Manning, J.E., Lucchesi, J.C. EMBO J. (1989) [Pubmed]
The genetic and cytogenetic localization of the three structural genes coding for the major protein of drosophila larval serum. Roberts, D.B., Evans-Roberts, S. Genetics (1979) [Pubmed]
Larval fat body-specific gene expression in D. melanogaster. Deutsch, J., Laval, M., Lepesant, J.A., Maschat, F., Pourrain, F., Rat, L. Dev. Genet. (1989) [Pubmed]
The non-dosage compensated LSP1-alpha gene of Drosophila melanogaster lies immediately downstream of the dosage compensated L12 gene. Ghosh, S., Lucchesi, J.C., Manning, J.E. Mol. Gen. Genet. (1992) [Pubmed]
A role for the adult fat body in Drosophila male courtship behavior. Lazareva, A.A., Roman, G., Mattox, W., Hardin, P.E., Dauwalder, B. PLoS Genet. (2007) [Pubmed]

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