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Gene Review

Lsp1gamma  -  Larval serum protein 1 gamma

Drosophila melanogaster

Synonyms: CG6821, DmeLSP1g, Dmel\CG6821, Hexamerin-1-gamma, LSP 1, ...
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Disease relevance of Lsp1gamma

  • We have isolated chromosomal segments of D. melanogaster DNA that encode the alpha, beta and gamma polypeptides of the major larval serum protein (LSP1) from libraries of recombinant phage [1].

High impact information on Lsp1gamma

  • Assays of CAT activity in the homogenates of dissected tissues indicated that the genes are only expressed in the fat body, as are the endogenous LSP1 genes [2].
  • Expression of the prokaryotic gene for chloramphenicol acetyl transferase in Drosophila under the control of larval serum protein 1 gene promoters [2].
  • We have linked the protein coding region of the prokaryotic gene for chloramphenicol acetyl transferase (CAT) to the promoter region of the Drosophila genes for larval serum protein 1 (LSP1) [2].
  • We have determined the nucleotide sequence at the 5' ends of the genes for the alpha, beta and gamma polypeptides of larval serum protein 1 (LSP1) of Drosophila melanogaster [3].
  • CAT expression occurs in approximately 1% of the cultured cells following transfection and the accumulation of protein is maximal three to four days after transfection; and it is dependent upon the presence of the LSP1 sequences [2].

Biological context of Lsp1gamma

  • In the Drosophila melanogaster genome, three Larval serum protein 1 (Lsp1) genes (alpha, beta and gamma) are present and each of them is located on a different chromosome, suggesting multiple transposition events [4].
  • Taken together these data indicate that the 1.65 X 10(3) and 2.25 X 10(3) base segments of DNA upstream from the LSP1 alpha and LSP1 beta genes contain cis-acting regulatory elements necessary for correct tissue and temporal specificity of LSP1 gene expression [2].
  • The results obtained demonstrate that the LSP-1 subunit genes are present in equal copies in the genome [5].
  • Short intervening sequences close to the 5' ends of the three Drosophila larval serum protein 1 genes [6].
  • A family of genes coding for larval serum proteins do not respond similarly in trisomies, suggesting that regulation operates on a process which is not common to their coordinate regulation [7].

Anatomical context of Lsp1gamma


Associations of Lsp1gamma with chemical compounds

  • Two-dimensional peptide mapping of the methionine-containing tryptic peptides showed that half of these peptides are common to all four larval serum protein subunits, and that about two-thirds are common to the three LSP-1 subunits [9].

Other interactions of Lsp1gamma

  • The same chromosomal localization and genomic organization, different from that of D. melanogaster, is found in both species for the Lsp1beta and Lsp1gamma genes [4].
  • Proteins 9, 10, 11, and 15 correspond to the LSP-1 gamma, beta, and alpha triplet and LSP-2 polypeptide in D. melanogaster [10].

Analytical, diagnostic and therapeutic context of Lsp1gamma


  1. The molecular cloning of a dispersed set of developmentally regulated genes which encode the major larval serum protein of D. melanogaster. Smith, D.F., McClelland, A., White, B.N., Addison, C.F., Glover, D.M. Cell (1981) [Pubmed]
  2. Expression of the prokaryotic gene for chloramphenicol acetyl transferase in Drosophila under the control of larval serum protein 1 gene promoters. Davies, J.A., Addison, C.F., Delaney, S.J., Sunkel, C., Glover, D.M. J. Mol. Biol. (1986) [Pubmed]
  3. Sequence conservation around the 5' ends of the larval serum protein 1 genes of Drosophila melanogaster. Delaney, S.J., Smith, D.F., McClelland, A., Sunkel, C., Glover, D.M. J. Mol. Biol. (1986) [Pubmed]
  4. Duplicative and conservative transpositions of larval serum protein 1 genes in the genus Drosophila. González, J., Casals, F., Ruiz, A. Genetics (2004) [Pubmed]
  5. Quantitative in situ hybridization reveals extent of sequence homology between related DNA sequences in Drosophila melanogaster. Brock, H.W., Roberts, D.B. Chromosoma (1981) [Pubmed]
  6. Short intervening sequences close to the 5' ends of the three Drosophila larval serum protein 1 genes. McClelland, A., Smith, D.F., Glover, D.M. J. Mol. Biol. (1981) [Pubmed]
  7. The influence of whole-arm trisomy on gene expression in Drosophila. Devlin, R.H., Holm, D.G., Grigliatti, T.A. Genetics (1988) [Pubmed]
  8. Ecdysone-regulation of synthesis and processing of fat body protein 1, the larval serum protein receptor of Drosophila melanogaster. Burmester, T., Antoniewski, C., Lepesant, J.A. Eur. J. Biochem. (1999) [Pubmed]
  9. Comparison of the larval serum proteins of Drosophila melanogaster using one and two-dimensional peptide mapping. Brock, H.W., Roberts, D.B. Eur. J. Biochem. (1980) [Pubmed]
  10. The existence of LSP-1 beta S in Drosophila melanogaster natural populations in two northern states. Band, H.T., Band, R.N., Ives, P.T. Biochem. Genet. (1984) [Pubmed]
  11. Regulation of synthesis of larval serum proteins after transplantation of larval fat body into adult Drosophila melanogaster. Jowett, T., Rizki, T.M., Rizki, R.M. Dev. Biol. (1986) [Pubmed]
  12. Temporally regulated protein synthesis in cultured haemocytes of the Mediterranean fruit fly Ceratitis capitata during larval and prepupal development: internalization of larval serum proteins into the haemocytes. Marmaras, V.J., Tsakas, S. Dev. Biol. (1988) [Pubmed]
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