The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Lsp2  -  Larval serum protein 2

Drosophila melanogaster

Synonyms: C23, CG11538, CG6806, DmeLSP2, Dmel\CG6806, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Lsp2

  • In this study aimed at developing a vaccine for humans, West Nile virus (WNV) envelope protein (E) and non-structural protein 1 (NS1) were produced in the Drosophila S2 cell expression system [1].

High impact information on Lsp2


Biological context of Lsp2


Anatomical context of Lsp2


Associations of Lsp2 with chemical compounds


Physical interactions of Lsp2

  • Proline-rich synapse-associated protein-1/cortactin binding protein 1 (ProSAP1/CortBP1) is a PDZ-domain protein highly enriched in the postsynaptic density [19].

Other interactions of Lsp2

  • Proteins 9, 10, 11, and 15 correspond to the LSP-1 gamma, beta, and alpha triplet and LSP-2 polypeptide in D. melanogaster [9].
  • Characterization of an EcR/USP heterodimer target site that mediates ecdysone responsiveness of the Drosophila Lsp-2 gene [10].
  • Induction was demonstrated by increased amounts of LSP-2 and P1 transcripts in the ecdysterone-supplemented fat bodies [4].
  • The Pl gene, together with the LSP-1 alpha, -1 beta, and -1 gamma, LSP-2, and P6 genes, is expressed exclusively in the larval fat body of D. melanogaster during the third instar [20].
  • After knockdown of fon by RNAi, bead aggregation activity of larval hemolymph is strongly reduced, and wound closure is affected. fon is thus the second Drosophila gene after hemolectin (hml), for which a knockdown causes a clotting phenotype [21].

Analytical, diagnostic and therapeutic context of Lsp2


  1. Preparation and immunogenic properties of a recombinant West Nile subunit vaccine. Lieberman, M.M., Clements, D.E., Ogata, S., Wang, G., Corpuz, G., Wong, T., Martyak, T., Gilson, L., Coller, B.A., Leung, J., Watts, D.M., Tesh, R.B., Siirin, M., Travassos da Rosa, A., Humphreys, T., Weeks-Levy, C. Vaccine (2007) [Pubmed]
  2. Drosophila: the genetics of two major larval proteins. Akam, M.E., Roberts, D.B., Richards, G.P., Ashburner, M. Cell (1978) [Pubmed]
  3. The LSP-2 gene and a 5' flanking sequence are independently expressed in Drosophila melanogaster. Yedvobnick, B., Levine, M. Nature (1982) [Pubmed]
  4. Selective gene expression induced by ecdysterone in cultured fat bodies of Drosophila. Nakanishi, Y., Garen, A. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  5. Illuminating the role of caspases during Drosophila oogenesis. Mazzalupo, S., Cooley, L. Cell Death Differ. (2006) [Pubmed]
  6. Organization and promoter analysis of the mouse dishevelled-1 gene. Lijam, N., Sussman, D.J. Genome Res. (1995) [Pubmed]
  7. The Drosophila Lsp-1 beta gene. A structural and phylogenetic analysis. Massey, H.C., Kejzlarová-Lepesant, J., Willis, R.L., Castleberry, A.B., Benes, H. Eur. J. Biochem. (1997) [Pubmed]
  8. Sequence, structure and evolution of the ecdysone-inducible Lsp-2 gene of Drosophila melanogaster. Mousseron-Grall, S., Kejzlarová-Lepesant, J., Burmester, T., Chihara, C., Barray, M., Delain, E., Pictet, R., Lepesant, J.A. Eur. J. Biochem. (1997) [Pubmed]
  9. The existence of LSP-1 beta S in Drosophila melanogaster natural populations in two northern states. Band, H.T., Band, R.N., Ives, P.T. Biochem. Genet. (1984) [Pubmed]
  10. Characterization of an EcR/USP heterodimer target site that mediates ecdysone responsiveness of the Drosophila Lsp-2 gene. Antoniewski, C., O'Grady, M.S., Edmondson, R.G., Lassieur, S.M., Benes, H. Mol. Gen. Genet. (1995) [Pubmed]
  11. Regulation of synthesis of larval serum proteins after transplantation of larval fat body into adult Drosophila melanogaster. Jowett, T., Rizki, T.M., Rizki, R.M. Dev. Biol. (1986) [Pubmed]
  12. The mammalian ARF-like protein 1 (Arl1) is associated with the Golgi complex. Lowe, S.L., Wong, S.H., Hong, W. J. Cell. Sci. (1996) [Pubmed]
  13. Drosophila hemolymph proteins: purification, characterization, and genetic mapping of larval serum protein 2 in D. melanogaster. Akam, M.E., Roberts, D.B., Wolfe, J. Biochem. Genet. (1978) [Pubmed]
  14. Fat-body-specific expression of the Drosophila Lsp-2 gene. Benes, H., Spivey, D.W., Miles, J., Neal, K., Edmondson, R.G. SAAS Bull. Biochem. Biotechnol. (1990) [Pubmed]
  15. The Drosophila semushi mutation blocks nuclear import of bicoid during embryogenesis. Epps, J.L., Tanda, S. Curr. Biol. (1998) [Pubmed]
  16. Genetic and environmental effects on the expression of peptidases and larval viability in Drosophila melanogaster. Hiraizumi, K., Tavormina, P.A., Mathes, K.D. Genetics (1992) [Pubmed]
  17. Can the insect nervous system synthesize ecdysteroids? Warren, J.T., Dai, J.D., Gilbert, L.I. Insect Biochem. Mol. Biol. (1999) [Pubmed]
  18. Characterisation of oligosaccharides from Drosophila melanogaster glycoproteins. Williams, P.J., Wormald, M.R., Dwek, R.A., Rademacher, T.W., Parker, G.F., Roberts, D.R. Biochim. Biophys. Acta (1991) [Pubmed]
  19. Proline-rich synapse-associated protein-1/cortactin binding protein 1 (ProSAP1/CortBP1) is a PDZ-domain protein highly enriched in the postsynaptic density. Boeckers, T.M., Kreutz, M.R., Winter, C., Zuschratter, W., Smalla, K.H., Sanmarti-Vila, L., Wex, H., Langnaese, K., Bockmann, J., Garner, C.C., Gundelfinger, E.D. Ann. Anat. (2001) [Pubmed]
  20. Larval fat body-specific gene expression in D. melanogaster. Deutsch, J., Laval, M., Lepesant, J.A., Maschat, F., Pourrain, F., Rat, L. Dev. Genet. (1989) [Pubmed]
  21. The Toll immune-regulated Drosophila protein Fondue is involved in hemolymph clotting and puparium formation. Scherfer, C., Qazi, M.R., Takahashi, K., Ueda, R., Dushay, M.S., Theopold, U., Lemaitre, B. Dev. Biol. (2006) [Pubmed]
  22. Adult expression of the Drosophila Lsp-2 gene. Benes, H., Edmondson, R.G., Fink, P., Kejzlarová-Lepesant, J., Lepesant, J.A., Miles, J.P., Spivey, D.W. Dev. Biol. (1990) [Pubmed]
  23. Parasite-induced enhancement of hemolymph tyrosinase activity in a selected immune reactive strain of Drosophila melanogaster. Nappi, A.J., Carton, Y., Frey, F. Arch. Insect Biochem. Physiol. (1991) [Pubmed]
  24. Relations between cuticular hydrocarbon (HC) polymorphism, resistance against desiccation and breeding temperature; a model for HC evolution in D. melanogaster and D. simulans. Rouault, J.D., Marican, C., Wicker-Thomas, C., Jallon, J.M. Genetica (2004) [Pubmed]
  25. Aldehyde oxidase cross-reacting material in the Aldoxn, cin, mal, and lxd mutants of Drosophila melanogaster. Browder, L.W., Wilkes, J., Tucker, L. Biochem. Genet. (1982) [Pubmed]
WikiGenes - Universities