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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

HOXC9  -  homeobox C9

Homo sapiens

Synonyms: HOX3, HOX3B, Homeobox protein Hox-3B, Homeobox protein Hox-C9
 
 
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High impact information on HOXC9

  • HOX3 contains at least 7 homeoboxes in 160 kb on chromosome 12 [1].
  • Our findings suggest that the expression of HOXB13, D9, D10, and HOXC cluster (HOXC9, C11-C13) genes might be an important step involved in cervical cancer [2].
  • The finished sequence from BAC clones from the genome of the sea urchin, Strongylocentrotus purpuratus, reveals a gene order wherein the anterior genes (Hox1, Hox2 and Hox3) lie nearest the posterior genes in the cluster such that the most 3' gene is Hox5 [3].
  • To determine the usefulness of this sequence for phylogenetic comparisons, we sequenced an 800-bp fragment of the Hoxc9-Hoxc8 intergenic region from several species belonging to different mammalian clades [4].

References

  1. The human HOX gene family. Acampora, D., D'Esposito, M., Faiella, A., Pannese, M., Migliaccio, E., Morelli, F., Stornaiuolo, A., Nigro, V., Simeone, A., Boncinelli, E. Nucleic Acids Res. (1989) [Pubmed]
  2. A subgroup of HOX Abd-B gene is differentially expressed in cervical cancer. López, R., Garrido, E., Vázquez, G., Piña, P., Pérez, C., Alvarado, I., Salcedo, M. Int. J. Gynecol. Cancer (2006) [Pubmed]
  3. Unusual gene order and organization of the sea urchin hox cluster. Cameron, R.A., Rowen, L., Nesbitt, R., Bloom, S., Rast, J.P., Berney, K., Arenas-Mena, C., Martinez, P., Lucas, S., Richardson, P.M., Davidson, E.H., Peterson, K.J., Hood, L. J. exp. zool. B. Mol. Dev. Evol. (2006) [Pubmed]
  4. Phylogenetic analysis of the mammalian Hoxc8 non-coding region. Kim, C.B., Shashikant, C.S., Sumiyama, K., Wang, W.C., Amemiya, C.T., Ruddle, F.H. J. Struct. Funct. Genomics (2003) [Pubmed]
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