The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Hoxc9  -  homeobox C9

Mus musculus

Synonyms: Homeobox protein Hox-3.2, Homeobox protein Hox-C9, Hox-3.2, Hoxc-9
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Hoxc9


Biological context of Hoxc9

  • This vector contained a short splice acceptor fragment from the Hoxc9 gene, a full length lacZ gene, including an ATG, and a reduced activity, mutant neomycin phosphotransferase gene as a selectable marker [4].
  • It is highly homologous to Hox-1.7 and Hox-3.2, demonstrating extended conservation among three homeo box complexes in the mouse [5].
  • Following the paradigm of phylogenetically conserved developmental control mechanisms, the Hoxc-9 intragenic enhancer was tested in Drosophila [6].
  • Our data show that the mouse Hoxc-9 enhancer acts in a conserved fashion in transgenic flies, conferring posteriorly restricted reporter gene expression to the developing central nervous system in third instar larvae [6].
  • Moreover, changes in the Hoxc-8 gene expression pattern suggested that the Hoxc-9 gene regulates expression of the Hoxc-8 gene [7].

Anatomical context of Hoxc9

  • Hoxc-9 mutant mice show anterior transformation of the vertebrae and malformation of the sternum and ribs [7].
  • However, separate localized expression was detected for Hoxc-9, -10, -11, -12 and possibly -13 in distal epidermal regions of the developing hind- and forelimb, whereas no expression of any of the five genes was observed in mesenchymal tissues of the developing forelimb [8].
  • A limited comparison of the primary expression domains of all five AbdB-related Hoxc genes in the developing hindlimb revealed nested and increasingly restricted domains of expression in the mesenchyme for only Hoxc-9, -10 and -11 [8].
  • The results demonstrated that Hoxc-9 mRNA was expressed at high levels in giant trophoblast cells of murine placentae on Days 12-19, but not on Day 8 [9].

Associations of Hoxc9 with chemical compounds


Analytical, diagnostic and therapeutic context of Hoxc9


  1. Primary structure and developmental expression pattern of Hox 3.1, a member of the murine Hox 3 homeobox gene cluster. Breier, G., Dressler, G.R., Gruss, P. EMBO J. (1988) [Pubmed]
  2. Structural analysis of the Hox-3.1 transcription unit and the Hox-3.2--Hox-3.1 intergenic region. Awgulewitsch, A., Bieberich, C., Bogarad, L., Shashikant, C., Ruddle, F.H. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  3. Structure and expression pattern of the murine Hox-3.2 gene. Erselius, J.R., Goulding, M.D., Gruss, P. Development (1990) [Pubmed]
  4. A new gene trap construct enriching for insertion events near the 5' end of genes. Thomas, T., Voss, A.K., Chowdhury, K., Gruss, P. Transgenic Res. (2000) [Pubmed]
  5. The developmental expression pattern of a new murine homeo box gene: Hox-2.5. Bogarad, L.D., Utset, M.F., Awgulewitsch, A., Miki, T., Hart, C.P., Ruddle, F.H. Dev. Biol. (1989) [Pubmed]
  6. Murine Hoxc-9 gene contains a structurally and functionally conserved enhancer. Papenbrock, T., Peterson, R.L., Lee, R.S., Hsu, T., Kuroiwa, A., Awgulewitsch, A. Dev. Dyn. (1998) [Pubmed]
  7. Hoxc-9 mutant mice show anterior transformation of the vertebrae and malformation of the sternum and ribs. Suemori, H., Takahashi, N., Noguchi, S. Mech. Dev. (1995) [Pubmed]
  8. The murine Hoxc cluster contains five neighboring AbdB-related Hox genes that show unique spatially coordinated expression in posterior embryonic subregions. Peterson, R.L., Papenbrock, T., Davda, M.M., Awgulewitsch, A. Mech. Dev. (1994) [Pubmed]
  9. Comparative analysis of HOXC-9 gene expression in murine hemochorial and caprine synepitheliochorial placentae by in situ hybridization. Murasawa, H., Takashima, R., Yamanouchi, K., Tojo, H., Tachi, C. Anat. Rec. (2000) [Pubmed]
WikiGenes - Universities