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Gene Review

HOXC8  -  homeobox C8

Homo sapiens

Synonyms: HOX3, HOX3A, Homeobox protein Hox-3A, Homeobox protein Hox-C8
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Disease relevance of HOXC8

  • Overexpression of HOXC8 in LNCaP prostate cancer cells suppressed transactivation by androgen receptors [1].
  • In order to analyze the self-delivery activity of Hoxc8, recombinant Hoxc8 protein (rHoxc8) was designed to be expressed and purified in E. coli as a glutathione S-transferase and green fluorescent protein-fused form (GST-GFP-Hoxc8) [2].

High impact information on HOXC8


Chemical compound and disease context of HOXC8


Biological context of HOXC8


Anatomical context of HOXC8


Physical interactions of HOXC8


Other interactions of HOXC8

  • Our data add weight to the body of evidence attributing to a specific adult tissue a particular combination of expressed HOX genes and suggest that HOXC5 and/or HOXC8 could be involved in the process leading to the transformation of cervical keratinocytes [10].
  • The interaction between Smad6 and Hoxc-8 was identified by a yeast two-hybrid approach and further demonstrated by co-immunoprecipitation assays in cells [12].
  • To determine the usefulness of this sequence for phylogenetic comparisons, we sequenced an 800-bp fragment of the Hoxc9-Hoxc8 intergenic region from several species belonging to different mammalian clades [13].

Analytical, diagnostic and therapeutic context of HOXC8


  1. Aberrant HOXC expression accompanies the malignant phenotype in human prostate. Miller, G.J., Miller, H.L., van Bokhoven, A., Lambert, J.R., Werahera, P.N., Schirripa, O., Lucia, M.S., Nordeen, S.K. Cancer Res. (2003) [Pubmed]
  2. Efficient cellular uptake of recombinant murine Hoxc8 homeoprotein in COS-7 cells. Lee, M.H., Park, H.W., Kim, M.H. Life Sci. (2006) [Pubmed]
  3. A nuclear antagonistic mechanism of inhibitory Smads in transforming growth factor-beta signaling. Bai, S., Cao, X. J. Biol. Chem. (2002) [Pubmed]
  4. Transcriptional mechanisms of bone morphogenetic protein-induced osteoprotegrin gene expression. Wan, M., Shi, X., Feng, X., Cao, X. J. Biol. Chem. (2001) [Pubmed]
  5. The human HOX gene family. Acampora, D., D'Esposito, M., Faiella, A., Pannese, M., Migliaccio, E., Morelli, F., Stornaiuolo, A., Nigro, V., Simeone, A., Boncinelli, E. Nucleic Acids Res. (1989) [Pubmed]
  6. Overexpression of the homeobox gene HOXC8 in human prostate cancer correlates with loss of tumor differentiation. Waltregny, D., Alami, Y., Clausse, N., de Leval, J., Castronovo, V. Prostate (2002) [Pubmed]
  7. Phosphorylation of the menin tumor suppressor protein on serine 543 and serine 583. Macconaill, L.E., Hughes, C.M., Rozenblatt-Rosen, O., Nannepaga, S., Meyerson, M. Mol. Cancer Res. (2006) [Pubmed]
  8. Unusual gene order and organization of the sea urchin hox cluster. Cameron, R.A., Rowen, L., Nesbitt, R., Bloom, S., Rast, J.P., Berney, K., Arenas-Mena, C., Martinez, P., Lucas, S., Richardson, P.M., Davidson, E.H., Peterson, K.J., Hood, L. J. exp. zool. B. Mol. Dev. Evol. (2006) [Pubmed]
  9. Molecular cloning, chromosomal assignment, and nucleotide sequence of the feline homeobox HOX3A. Masuda, R., Yuhki, N., O'Brien, S.J. Genomics (1991) [Pubmed]
  10. HOXC5 and HOXC8 expression are selectively turned on in human cervical cancer cells compared to normal keratinocytes. Alami, Y., Castronovo, V., Belotti, D., Flagiello, D., Clausse, N. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  11. Smads oppose Hox transcriptional activities. Li, X., Nie, S., Chang, C., Qiu, T., Cao, X. Exp. Cell Res. (2006) [Pubmed]
  12. Smad6 as a transcriptional corepressor. Bai, S., Shi, X., Yang, X., Cao, X. J. Biol. Chem. (2000) [Pubmed]
  13. Phylogenetic analysis of the mammalian Hoxc8 non-coding region. Kim, C.B., Shashikant, C.S., Sumiyama, K., Wang, W.C., Amemiya, C.T., Ruddle, F.H. J. Struct. Funct. Genomics (2003) [Pubmed]
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