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Gene Review

okr  -  okra

Drosophila melanogaster

Synonyms: CG3736, DNA repair and recombination protein RAD54-like, DhR54, DmRAD54, DmRad54, ...
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High impact information on okr


Biological context of okr

  • Of these, mutants deficient in DNA repair, mei-41 and okra, show progressive degeneration of imaginal discs and die as pupae, while other genotypes survive to adulthood after irradiation [4].
  • The genes okra and spindle-B act during meiosis in Drosophila to repair double-stranded DNA breaks (DSBs) associated with meiotic recombination [5].
  • To determine the function of DmRAD54, a null mutant was isolated by random mutagenesis [6].
  • PCR analysis indicated that the undamaged homologous chromosome may compensate for the potential loss of the broken chromosome in rad54 mutant females after excision [7].

Regulatory relationships of okr


Other interactions of okr

  • Mutations in the genes okra, mus309, and mei41 did not affect eccDNA under normal conditions or following mutagen treatment, implying that eccDNA formation is different from known pathways of DNA repair [9].
  • To determine the relative contribution of NHEJ and homologous recombination (HR) in Drosophila, Lig4; Rad54 double-mutant flies were generated [8].
  • Here we show that enc mutants also exhibit abnormalities in karyosome morphology, similar to other ventralizing mutants such as okra and spindle B [10].


  1. Strand pairing by Rad54 and Rad51 is enhanced by chromatin. Alexiadis, V., Kadonaga, J.T. Genes Dev. (2002) [Pubmed]
  2. okra and spindle-B encode components of the RAD52 DNA repair pathway and affect meiosis and patterning in Drosophila oogenesis. Ghabrial, A., Ray, R.P., Schüpbach, T. Genes Dev. (1998) [Pubmed]
  3. The Drosophila melanogaster DmRAD54 gene plays a crucial role in double-strand break repair after P-element excision and acts synergistically with Ku70 in the repair of X-ray damage. Kooistra, R., Pastink, A., Zonneveld, J.B., Lohman, P.H., Eeken, J.C. Mol. Cell. Biol. (1999) [Pubmed]
  4. Relative contribution of DNA repair, cell cycle checkpoints, and cell death to survival after DNA damage in Drosophila larvae. Jaklevic, B.R., Su, T.T. Curr. Biol. (2004) [Pubmed]
  5. Activation of a meiotic checkpoint regulates translation of Gurken during Drosophila oogenesis. Ghabrial, A., Schüpbach, T. Nat. Cell Biol. (1999) [Pubmed]
  6. The Drosophila melanogaster RAD54 homolog, DmRAD54, is involved in the repair of radiation damage and recombination. Kooistra, R., Vreeken, K., Zonneveld, J.B., de Jong, A., Eeken, J.C., Osgood, C.J., Buerstedde, J.M., Lohman, P.H., Pastink, A. Mol. Cell. Biol. (1997) [Pubmed]
  7. Lig4 and rad54 are required for repair of DNA double-strand breaks induced by P-element excision in Drosophila. Romeijn, R.J., Gorski, M.M., van Schie, M.A., Noordermeer, J.N., Mullenders, L.H., Ferro, W., Pastink, A. Genetics (2005) [Pubmed]
  8. The Drosophila melanogaster DNA Ligase IV gene plays a crucial role in the repair of radiation-induced DNA double-strand breaks and acts synergistically with Rad54. Gorski, M.M., Eeken, J.C., de Jong, A.W., Klink, I., Loos, M., Romeijn, R.J., van Veen, B.L., Mullenders, L.H., Ferro, W., Pastink, A. Genetics (2003) [Pubmed]
  9. Extrachromosomal circular DNA of tandemly repeated genomic sequences in Drosophila. Cohen, S., Yacobi, K., Segal, D. Genome Res. (2003) [Pubmed]
  10. Encore is a member of a novel family of proteins and affects multiple processes in Drosophila oogenesis. Van Buskirk, C., Hawkins, N.C., Schüpbach, T. Development (2000) [Pubmed]
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