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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Enteric Nervous System

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Disease relevance of Enteric Nervous System


Psychiatry related information on Enteric Nervous System


High impact information on Enteric Nervous System


Chemical compound and disease context of Enteric Nervous System


Biological context of Enteric Nervous System


Anatomical context of Enteric Nervous System


Associations of Enteric Nervous System with chemical compounds


Gene context of Enteric Nervous System

  • These results, and recent studies implicating GDNF and ET-3 in the patterning of the enteric nervous system, suggest that specific pairing of endothelins and neurotrophic factors may be used in distinct target organs to coordinate neuronal migration, differentiation, and survival [27].
  • Homozygous nonsense mutations in KIAA1279 are associated with malformations of the central and enteric nervous systems [1].
  • To clarify the role of Ret signaling components in enteric nervous system (ENS) development, we evaluated ENS anatomy and intestinal contractility in mice heterozygous for Ret, GFRalpha1 and Ret ligands [28].
  • However, the effects on the development of the enteric nervous system (ENS) promoted by a heterozygous mutation of the EDNRB gene are not known [29].
  • The defects in enteric nervous system development of mice with Sox10 and Sox8 mutations are therefore likely caused by a reduction of the pool of undifferentiated vagal neural crest cells [30].

Analytical, diagnostic and therapeutic context of Enteric Nervous System


  1. Homozygous nonsense mutations in KIAA1279 are associated with malformations of the central and enteric nervous systems. Brooks, A.S., Bertoli-Avella, A.M., Burzynski, G.M., Breedveld, G.J., Osinga, J., Boven, L.G., Hurst, J.A., Mancini, G.M., Lequin, M.H., de Coo, R.F., Matera, I., de Graaff, E., Meijers, C., Willems, P.J., Tibboel, D., Oostra, B.A., Hofstra, R.M. Am. J. Hum. Genet. (2005) [Pubmed]
  2. Inhibitory effect of experimental colitis on fluid absorption in rat jejunum: role of the enteric nervous system, VIP, and nitric oxide. Mourad, F.H., Barada, K.A., Bou Rached, N.A., Khoury, C.I., Saadé, N.E., Nassar, C.F. Am. J. Physiol. Gastrointest. Liver Physiol. (2006) [Pubmed]
  3. Decreased substance P levels in rectal biopsies from patients with slow transit constipation. Tzavella, K., Riepl, R.L., Klauser, A.G., Voderholzer, W.A., Schindlbeck, N.E., Müller-Lissner, S.A. European journal of gastroenterology & hepatology. (1996) [Pubmed]
  4. On the role of vasoactive intestinal polypeptide and tachykinins in the secretory reflex elicited by chemical peritonitis in the cat small intestine. Brunsson, I., Fahrenkrug, J., Jodal, M., Sjöqvist, A., Theodorsson, E., Lundgren, O. Acta Physiol. Scand. (1990) [Pubmed]
  5. Chick sox10, a transcription factor expressed in both early neural crest cells and central nervous system. Cheng, Y., Cheung, M., Abu-Elmagd, M.M., Orme, A., Scotting, P.J. Brain Res. Dev. Brain Res. (2000) [Pubmed]
  6. Studies of the enteric nervous system in Alzheimer disease and other dementias of the elderly: enteric neurons in Alzheimer disease. Shankle, W.R., Landing, B.H., Ang, S.M., Chui, H., Villarreal-Engelhardt, G., Zarow, C. Mod. Pathol. (1993) [Pubmed]
  7. Spatiotemporal regulation of endothelin receptor-B by SOX10 in neural crest-derived enteric neuron precursors. Zhu, L., Lee, H.O., Jordan, C.S., Cantrell, V.A., Southard-Smith, E.M., Shin, M.K. Nat. Genet. (2004) [Pubmed]
  8. Cellular prion protein is expressed in the human enteric nervous system. Shmakov, A.N., McLennan, N.F., McBride, P., Farquhar, C.F., Bode, J., Rennison, K.A., Ghosh, S. Nat. Med. (2000) [Pubmed]
  9. Characterization of a multicomponent receptor for GDNF. Treanor, J.J., Goodman, L., de Sauvage, F., Stone, D.M., Poulsen, K.T., Beck, C.D., Gray, C., Armanini, M.P., Pollock, R.A., Hefti, F., Phillips, H.S., Goddard, A., Moore, M.W., Buj-Bello, A., Davies, A.M., Asai, N., Takahashi, M., Vandlen, R., Henderson, C.E., Rosenthal, A. Nature (1996) [Pubmed]
  10. GDNF signalling through the Ret receptor tyrosine kinase. Durbec, P., Marcos-Gutierrez, C.V., Kilkenny, C., Grigoriou, M., Wartiowaara, K., Suvanto, P., Smith, D., Ponder, B., Costantini, F., Saarma, M. Nature (1996) [Pubmed]
  11. Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret. Schuchardt, A., D'Agati, V., Larsson-Blomberg, L., Costantini, F., Pachnis, V. Nature (1994) [Pubmed]
  12. The sensitivity of activated Cys Ret mutants to glial cell line-derived neurotrophic factor is mandatory to rescue neuroectodermic cells from apoptosis. Mograbi, B., Bocciardi, R., Bourget, I., Juhel, T., Farahi-Far, D., Romeo, G., Ceccherini, I., Rossi, B. Mol. Cell. Biol. (2001) [Pubmed]
  13. Nitric oxide synthase and VIP distribution in enteric nervous system in idiopathic chronic constipation. Cortesini, C., Cianchi, F., Infantino, A., Lise, M. Dig. Dis. Sci. (1995) [Pubmed]
  14. Differential activities of the RET tyrosine kinase receptor isoforms during mammalian embryogenesis. de Graaff, E., Srinivas, S., Kilkenny, C., D'Agati, V., Mankoo, B.S., Costantini, F., Pachnis, V. Genes Dev. (2001) [Pubmed]
  15. Transgenic expression of the endothelin-B receptor prevents congenital intestinal aganglionosis in a rat model of Hirschsprung disease. Gariepy, C.E., Williams, S.C., Richardson, J.A., Hammer, R.E., Yanagisawa, M. J. Clin. Invest. (1998) [Pubmed]
  16. Endothelin-B receptor is expressed by neural crest cells in the avian embryo. Nataf, V., Lecoin, L., Eichmann, A., Le Douarin, N.M. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  17. Functional haplotypes of the RET proto-oncogene promoter are associated with Hirschsprung disease (HSCR). Fitze, G., Appelt, H., König, I.R., Görgens, H., Stein, U., Walther, W., Gossen, M., Schreiber, M., Ziegler, A., Roesner, D., Schackert, H.K. Hum. Mol. Genet. (2003) [Pubmed]
  18. G protein-mediated inhibition of neuronal migration requires calcium influx. Horgan, A.M., Copenhaver, P.F. J. Neurosci. (1998) [Pubmed]
  19. Glial cells in the enteric nervous system contain glial fibrillary acidic protein. Jessen, K.R., Mirsky, R. Nature (1980) [Pubmed]
  20. GFRalpha1 is an essential receptor component for GDNF in the developing nervous system and kidney. Cacalano, G., Fariñas, I., Wang, L.C., Hagler, K., Forgie, A., Moore, M., Armanini, M., Phillips, H., Ryan, A.M., Reichardt, L.F., Hynes, M., Davies, A., Rosenthal, A. Neuron (1998) [Pubmed]
  21. Vagal stimulation of rat exocrine pancreatic secretion occurs via multiple mediators. Nelson, M.T., Debas, H.T., Mulvihill, S.J. Gastroenterology (1993) [Pubmed]
  22. The effect of capsaicin on gallbladder fluid absorption. Fitzgerald, S., Deshpande, Y.G., Nguyen, H.Q., Kaminski, D.L. Hepatology (1991) [Pubmed]
  23. GABA affects the release of gastrin and somatostatin from rat antral mucosa. Harty, R.F., Franklin, P.A. Nature (1983) [Pubmed]
  24. Hydrogen peroxide stimulates rat colonic prostaglandin production and alters electrolyte transport. Karayalcin, S.S., Sturbaum, C.W., Wachsman, J.T., Cha, J.H., Powell, D.W. J. Clin. Invest. (1990) [Pubmed]
  25. Expression of substance P/neurokinin A-encoding preprotachykinin messenger ribonucleic acids in the rat enteric nervous system. Sternini, C., Anderson, K., Frantz, G., Krause, J.E., Brecha, N. Gastroenterology (1989) [Pubmed]
  26. Neural stem cell transplantation in the stomach rescues gastric function in neuronal nitric oxide synthase-deficient mice. Micci, M.A., Kahrig, K.M., Simmons, R.S., Sarna, S.K., Espejo-Navarro, M.R., Pasricha, P.J. Gastroenterology (2005) [Pubmed]
  27. Sculpting organ innervation. Hempstead, B.L. J. Clin. Invest. (2004) [Pubmed]
  28. GDNF availability determines enteric neuron number by controlling precursor proliferation. Gianino, S., Grider, J.R., Cresswell, J., Enomoto, H., Heuckeroth, R.O. Development (2003) [Pubmed]
  29. Abnormalities of the enteric nervous system in heterozygous endothelin B receptor deficient (spotting lethal) rats resembling intestinal neuronal dysplasia. von Boyen, G.B., Krammer, H.J., Süss, A., Dembowski, C., Ehrenreich, H., Wedel, T. Gut (2002) [Pubmed]
  30. Identification of Sox8 as a modifier gene in a mouse model of Hirschsprung disease reveals underlying molecular defect. Maka, M., Stolt, C.C., Wegner, M. Dev. Biol. (2005) [Pubmed]
  31. Isolation, structure, synthesis, and activity of a new member of the calcitonin gene-related peptide family from frog skin and molecular cloning of its precursor. Seon, A.A., Pierre, T.N., Redeker, V., Lacombe, C., Delfour, A., Nicolas, P., Amiche, M. J. Biol. Chem. (2000) [Pubmed]
  32. Expression of type 1 corticotropin-releasing factor receptor in the guinea pig enteric nervous system. Liu, S., Gao, X., Gao, N., Wang, X., Fang, X., Hu, H.Z., Wang, G.D., Xia, Y., Wood, J.D. J. Comp. Neurol. (2005) [Pubmed]
  33. Recent progress in studies of neurotrophic factors and their clinical implications. Shen, L., Figurov, A., Lu, B. J. Mol. Med. (1997) [Pubmed]
  34. Neurogenic mechanism of action of motilin in the canine isolated small intestine ex vivo. Hirning, L.D., Burks, T.F. Eur. J. Pharmacol. (1986) [Pubmed]
  35. Effects of total parenteral nutrition on rat enteric nervous system, intestinal morphology, and motility. Ekelund, M., Ekelund, M., Qader, S.S., Hallén, M., Ekblad, E. J. Surg. Res. (2005) [Pubmed]
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