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Gene Review:

GOX1996 - decaprenyl diphosphate synthase

Gluconobacter oxydans 621H

Kim, S.J. et al., Park, Y.C. et al., Liu, X. et al., Okada, K. et al.

Park, Kim, Choi, Lee, Park, Kawamukai, Ryu, Seo,

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Disease relevance of GOX1996

Molecular cloning and mutational analysis of the ddsA gene encoding decaprenyl diphosphate synthase from Gluconobacter suboxydans [1].
Batch and fed-batch production of coenzyme Q10 in recombinant Escherichia coli containing the decaprenyl diphosphate synthase gene from Gluconobacter suboxydans [2].
For the enhancement of coenzyme Q(10) (CoQ(10)) production, 1-deoxy-D: -xylulose 5-phosphate (DXP) synthase of Pseudomonas aeruginosa was constitutively coexpressed in a recombinant Escherichia coli strain, which harbors the ddsA gene from Gluconobacter suboxydans encoding decaprenyl diphosphate synthase [3].

High impact information on GOX1996

Decaprenyl diphosphate synthase (DPS) is the key enzyme for synthesis of the decaprenyl tail in CoQ(10) with isopentenyl diphosphate [2].
Nineteen mutants of decaprenyl diphosphate synthase from Gluconobacter suboxydans were generated and their production of ubiquinones (UQs) was compared to that of the wild type protein [4].

References

Molecular cloning and mutational analysis of the ddsA gene encoding decaprenyl diphosphate synthase from Gluconobacter suboxydans. Okada, K., Kainou, T., Tanaka, K., Nakagawa, T., Matsuda, H., Kawamukai, M. Eur. J. Biochem. (1998) [Pubmed]
Batch and fed-batch production of coenzyme Q10 in recombinant Escherichia coli containing the decaprenyl diphosphate synthase gene from Gluconobacter suboxydans. Park, Y.C., Kim, S.J., Choi, J.H., Lee, W.H., Park, K.M., Kawamukai, M., Ryu, Y.W., Seo, J.H. Appl. Microbiol. Biotechnol. (2005) [Pubmed]
Amplification of 1-deoxy-D: -xyluose 5-phosphate (DXP) synthase level increases coenzyme Q(10) production in recombinant Escherichia coli. Kim, S.J., Kim, M.D., Choi, J.H., Kim, S.Y., Ryu, Y.W., Seo, J.H. Appl. Microbiol. Biotechnol. (2006) [Pubmed]
Residues Around the Catalytic Pocket of DdsA Are Important for Isoprenoids Chain Elongation. Liu, X., Yuan, Q., Zhang, H. Protein Pept. Lett. (2007) [Pubmed]

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