The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Coenzyme Q     2-[ (2E,6E,10E,14E,18E,22E,26E,30E ,34E)-3,7...

Synonyms: Emitolon, Heartcin, Inokiten, Udekinon, Armolipid, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Coenzyme Q


Psychiatry related information on Coenzyme Q


High impact information on Coenzyme Q


Chemical compound and disease context of Coenzyme Q


Biological context of Coenzyme Q


Anatomical context of Coenzyme Q


Associations of Coenzyme Q with other chemical compounds


Gene context of Coenzyme Q

  • Reconstitution of recombinant uncoupling proteins: UCP1, -2, and -3 have similar affinities for ATP and are unaffected by coenzyme Q10 [28].
  • RECENT FINDINGS: Most recently described mitochondrial myopathies are due to defects in nuclear DNA, including coenzyme Q10 deficiency, and mutations in genes that control mitochondrial DNA (mtDNA) abundance and structure such as POLG and TK2 [29].
  • MTtrans and alpha-Syn(ko) mice were genetically resistant to MPTP-Parkinsonism and Ames dwarf mice possessed significantly higher concentrations of striatal coenzyme Q10 and metallothioneins (MT 1, 2) and lived almost 2.5 times longer as compared to control(wt) mice [30].
  • Dietary coenzyme Q10 supplementation alters platelet size and inhibits human vitronectin (CD51/CD61) receptor expression [31].
  • A Mutation in Para-Hydroxybenzoate-Polyprenyl Transferase (COQ2) Causes Primary Coenzyme Q10 Deficiency [32].

Analytical, diagnostic and therapeutic context of Coenzyme Q


  1. Protection against anthramycin-induced toxicity in mice by coenzyme Q10. Lubawy, W.C., Dallam, R.A., Hurley, L.H. J. Natl. Cancer Inst. (1980) [Pubmed]
  2. The effect of coenzyme Q10 in patients with congestive heart failure. Khatta, M., Alexander, B.S., Krichten, C.M., Fisher, M.L., Freudenberger, R., Robinson, S.W., Gottlieb, S.S. Ann. Intern. Med. (2000) [Pubmed]
  3. Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects. Matthews, R.T., Yang, L., Browne, S., Baik, M., Beal, M.F. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  4. Biochemical rationale and the cardiac response of patients with muscle disease to therapy with coenzyme Q10. Folkers, K., Wolaniuk, J., Simonsen, R., Morishita, M., Vadhanavikit, S. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  5. Energy metabolism defects in Huntington's disease and effects of coenzyme Q10. Koroshetz, W.J., Jenkins, B.G., Rosen, B.R., Beal, M.F. Ann. Neurol. (1997) [Pubmed]
  6. Concurrent administration of coenzyme Q10 and alpha-tocopherol improves learning in aged mice. McDonald, S.R., Sohal, R.S., Forster, M.J. Free Radic. Biol. Med. (2005) [Pubmed]
  7. Serum levels of coenzyme Q10 in patients with Alzheimer's disease. de Bustos, F., Molina, J.A., Jiménez-Jiménez, F.J., García-Redondo, A., Gómez-Escalonilla, C., Porta-Etessam, J., Berbel, A., Zurdo, M., Barcenilla, B., Parrilla, G., Enriquez-de-Salamanca, R., Arenas, J. Journal of neural transmission (Vienna, Austria : 1996) (2000) [Pubmed]
  8. Attenuation of cocaine and methamphetamine neurotoxicity by coenzyme Q10. Klongpanichapak, S., Govitrapong, P., Sharma, S.K., Ebadi, M. Neurochem. Res. (2006) [Pubmed]
  9. Muscle coenzyme Q10 deficiencies in ataxia with oculomotor apraxia 1. Le Ber, I., Dubourg, O., Benoist, J.F., Jardel, C., Mochel, F., Koenig, M., Brice, A., Lombès, A., Dürr, A. Neurology (2007) [Pubmed]
  10. Quinone-responsive multiple respiratory-chain dysfunction due to widespread coenzyme Q10 deficiency. Rötig, A., Appelkvist, E.L., Geromel, V., Chretien, D., Kadhom, N., Edery, P., Lebideau, M., Dallner, G., Munnich, A., Ernster, L., Rustin, P. Lancet (2000) [Pubmed]
  11. Improvement of abnormal pyruvate metabolism and cardiac conduction defect with coenzyme Q10 in Kearns-Sayre syndrome. Ogasahara, S., Yorifuji, S., Nishikawa, Y., Takahashi, M., Wada, K., Hazama, T., Nakamura, Y., Hashimoto, S., Kono, N., Tarui, S. Neurology (1985) [Pubmed]
  12. Effect of coenzyme Q10 on experimental atherosclerosis and chemical composition and quality of atheroma in rabbits. Singh, R.B., Shinde, S.N., Chopra, R.K., Niaz, M.A., Thakur, A.S., Onouchi, Z. Atherosclerosis (2000) [Pubmed]
  13. Effects of long-term coenzyme Q10 and captopril treatment on survival and functional capacity in rats with experimentally induced heart infarction. Bech, O.M., Sørensen, J.D., Jensen, M.K., Diamant, B., Steiness, E. J. Pharmacol. Exp. Ther. (1990) [Pubmed]
  14. Systemic markers of lipid peroxidation and antioxidants in patients with nonalcoholic Fatty liver disease. Yesilova, Z., Yaman, H., Oktenli, C., Ozcan, A., Uygun, A., Cakir, E., Sanisoglu, S.Y., Erdil, A., Ates, Y., Aslan, M., Musabak, U., Erbil, M.K., Karaeren, N., Dagalp, K. Am. J. Gastroenterol. (2005) [Pubmed]
  15. Ubiquinone (coenzyme q10) and mitochondria in oxidative stress of parkinson's disease. Ebadi, M., Govitrapong, P., Sharma, S., Muralikrishnan, D., Shavali, S., Pellett, L., Schafer, R., Albano, C., Eken, J. Biological signals and receptors. (2001) [Pubmed]
  16. Response of patients in classes III and IV of cardiomyopathy to therapy in a blind and crossover trial with coenzyme Q10. Langsjoen, P.H., Vadhanavikit, S., Folkers, K. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  17. In vivo supplementation with coenzyme Q10 enhances the recovery of human lymphocytes from oxidative DNA damage. Tomasetti, M., Alleva, R., Borghi, B., Collins, A.R. FASEB J. (2001) [Pubmed]
  18. Coenzyme q10 prevents apoptosis by inhibiting mitochondrial depolarization independently of its free radical scavenging property. Papucci, L., Schiavone, N., Witort, E., Donnini, M., Lapucci, A., Tempestini, A., Formigli, L., Zecchi-Orlandini, S., Orlandini, G., Carella, G., Brancato, R., Capaccioli, S. J. Biol. Chem. (2003) [Pubmed]
  19. Statins and chronic heart failure: do we need a large-scale outcome trial? Krum, H., McMurray, J.J. J. Am. Coll. Cardiol. (2002) [Pubmed]
  20. Maternally inherited diabetes and deafness in a north american kindred: tips for making the diagnosis and review of unique management issues. Donovan, L.E., Severin, N.E. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
  21. Coenzyme Q reductase from liver plasma membrane: purification and role in trans-plasma-membrane electron transport. Villalba, J.M., Navarro, F., Córdoba, F., Serrano, A., Arroyo, A., Crane, F.L., Navas, P. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  22. Requirement for coenzyme Q in plasma membrane electron transport. Sun, I.L., Sun, E.E., Crane, F.L., Morré, D.J., Lindgren, A., Löw, H. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  23. Coenzyme Q10 levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects. Shults, C.W., Haas, R.H., Passov, D., Beal, M.F. Ann. Neurol. (1997) [Pubmed]
  24. Antioxidant treatment improves in vivo cardiac and skeletal muscle bioenergetics in patients with Friedreich's ataxia. Lodi, R., Hart, P.E., Rajagopalan, B., Taylor, D.J., Crilley, J.G., Bradley, J.L., Blamire, A.M., Manners, D., Styles, P., Schapira, A.H., Cooper, J.M. Ann. Neurol. (2001) [Pubmed]
  25. Coenzyme Q10 and nicotinamide block striatal lesions produced by the mitochondrial toxin malonate. Beal, M.F., Henshaw, D.R., Jenkins, B.G., Rosen, B.R., Schulz, J.B. Ann. Neurol. (1994) [Pubmed]
  26. Identification of ubiquinone-50 as the major methylated nonpolar lipid in human monocytes. Regulation of its biosynthesis via methionine-dependent pathways and relationship to superoxide production. Bougnoux, P., Bonvini, E., Stevenson, H.C., Markey, S., Zatz, M., Hoffman, T. J. Biol. Chem. (1983) [Pubmed]
  27. Plasma antioxidants in pediatric patients with glycogen storage disease, diabetes mellitus, and hypercholesterolemia. Wittenstein, B., Klein, M., Finckh, B., Ullrich, K., Kohlschütter, A. Free Radic. Biol. Med. (2002) [Pubmed]
  28. Reconstitution of recombinant uncoupling proteins: UCP1, -2, and -3 have similar affinities for ATP and are unaffected by coenzyme Q10. Jaburek, M., Garlid, K.D. J. Biol. Chem. (2003) [Pubmed]
  29. The expanding phenotype of mitochondrial myopathy. DiMauro, S., Gurgel-Giannetti, J. Curr. Opin. Neurol. (2005) [Pubmed]
  30. Metallothionein-mediated neuroprotection in genetically engineered mouse models of Parkinson's disease. Ebadi, M., Brown-Borg, H., El Refaey, H., Singh, B.B., Garrett, S., Shavali, S., Sharma, S.K. Brain Res. Mol. Brain Res. (2005) [Pubmed]
  31. Dietary coenzyme Q10 supplementation alters platelet size and inhibits human vitronectin (CD51/CD61) receptor expression. Serebruany, V.L., Ordonez, J.V., Herzog, W.R., Rohde, M., Mortensen, S.A., Folkers, K., Gurbel, P.A. J. Cardiovasc. Pharmacol. (1997) [Pubmed]
  32. A Mutation in Para-Hydroxybenzoate-Polyprenyl Transferase (COQ2) Causes Primary Coenzyme Q10 Deficiency. Quinzii, C., Naini, A., Salviati, L., Trevisson, E., Navas, P., Dimauro, S., Hirano, M. Am. J. Hum. Genet. (2006) [Pubmed]
  33. Biochemical rationale and myocardial tissue data on the effective therapy of cardiomyopathy with coenzyme Q10. Folkers, K., Vadhanavikit, S., Mortensen, S.A. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  34. Chemotherapy induces an increase in coenzyme Q10 levels in cancer cell lines. Brea-Calvo, G., Rodríguez-Hernández, A., Fernández-Ayala, D.J., Navas, P., Sánchez-Alcázar, J.A. Free Radic. Biol. Med. (2006) [Pubmed]
  35. The impact of alpha-lipoic acid, coenzyme Q10 and caloric restriction on life span and gene expression patterns in mice. Lee, C.K., Pugh, T.D., Klopp, R.G., Edwards, J., Allison, D.B., Weindruch, R., Prolla, T.A. Free Radic. Biol. Med. (2004) [Pubmed]
WikiGenes - Universities