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Gene Review

sopB  -  stabilization of plasmid protein B

Salmonella typhimurium

 
 
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Disease relevance of sopB

  • We conclude that host cell invasion emerged early during evolution by acquisition of a mosaic of genetic elements (SPI1 itself, SPI5 [sopB], and sopE2) and that the last common ancestor of all contemporary Salmonella spp. was probably already invasive [1].
 

High impact information on sopB

  • Mutations of both sopB and sopD significantly reduced, but did not abrogate, the enteropathogenic phenotype [2].
  • All serotype Paratyphi B strains from systemic infections have been found to be somewhat genetically related with respect to the pattern of their virulence genes sopB, sopD, sopE1, avrA, and sptP as well as other molecular properties (multilocus enzyme electrophoresis type, pulsed-field gel electrophoresis [PFGE] type, ribotype, and IS200 type) [3].
  • Surprisingly, the same holds true for several effector protein genes located in distant regions of the Salmonella chromosome, namely, sopB (SPI5, centisome 20), sopD (centisome 64), and sopE2 (centisomes 40 to 42) [1].
 

Analytical, diagnostic and therapeutic context of sopB

  • Individual and multiple polymerase chain reaction (PCR) analyses revealed the presence of the virulence genes invA, aceK and sopB and the absence of the h-1i gene in all isolates [4].
  • The incorporation of an additional mutation into the sopB locus of the attenuated sseC, phoP and aroA mutants resulted in the stimulation of improved humoral and cellular immune responses following oral vaccination [5].
  • Of these, 41 isolates were found to express sopB gene phenotypically as detected by dot- ELISA using anti-SopB serum [6].

References

  1. Salmonella host cell invasion emerged by acquisition of a mosaic of separate genetic elements, including Salmonella pathogenicity island 1 (SPI1), SPI5, and sopE2. Mirold, S., Ehrbar, K., Weissmüller, A., Prager, R., Tschäpe, H., Rüssmann, H., Hardt, W.D. J. Bacteriol. (2001) [Pubmed]
  2. The secreted effector protein of Salmonella dublin, SopA, is translocated into eukaryotic cells and influences the induction of enteritis. Wood, M.W., Jones, M.A., Watson, P.R., Siber, A.M., McCormick, B.A., Hedges, S., Rosqvist, R., Wallis, T.S., Galyov, E.E. Cell. Microbiol. (2000) [Pubmed]
  3. Molecular properties of Salmonella enterica serotype paratyphi B distinguish between its systemic and its enteric pathovars. Prager, R., Rabsch, W., Streckel, W., Voigt, W., Tietze, E., Tschäpe, H. J. Clin. Microbiol. (2003) [Pubmed]
  4. Genetic diversity and virulence gene determinants of antibiotic-resistant Salmonella isolated from preharvest turkey production sources. Nayak, R., Stewart, T., Wang, R.F., Lin, J., Cerniglia, C.E., Kenney, P.B. Int. J. Food Microbiol. (2004) [Pubmed]
  5. An SopB-mediated immune escape mechanism of Salmonella enterica can be subverted to optimize the performance of live attenuated vaccine carrier strains. Link, C., Ebensen, T., Ständner, L., Déjosez, M., Reinhard, E., Rharbaoui, F., Guzmán, C.A. Microbes Infect. (2006) [Pubmed]
  6. Prevalence & phenotypic expression of sopB gene among clinical isolates of Salmonella enterica. Rahman, H. Indian J. Med. Res. (2006) [Pubmed]
 
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