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Gene Review

Iddm3  -  Insulin dependent diabetes mellitus QTL 3

Rattus norvegicus

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Disease relevance of Iddm3


High impact information on Iddm3

  • Using diabetic BB/OK and diabetes-resistant DA rats it has been shown that a third non-MHC gene, Iddm3, on chromosome 18 cosegregates with diabetes in the BB/OK rat subline [2].

Biological context of Iddm3

  • The percentage of diabetics in Iddm1 and Iddm2 homozygotes confirmed the existence of the third gene, Iddm3, but there were some sex differences; significantly more male than female BC1W-F and significantly more BC1DA-M than BC1DA-F males were diabetic [3].


  1. Alleles of diabetes-resistant BN rats contribute to insulin-dependent type 1 diabetes mellitus. Klöting, I., van den Brandt, J., Klöting, N., Radović, B. J. Autoimmun. (2003) [Pubmed]
  2. Mapping of novel genes predisposing or protecting diabetes development in the BB/OK rat. Klöting, I., Schmidt, S., Kovacs, P. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  3. Crosses between diabetic BB/OK and wild rats confirm that a third gene is essential for diabetes development. Klöting, I., Kovacs, P. Acta diabetologica. (1998) [Pubmed]
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