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Gene Review:

Iddm3 - Insulin dependent diabetes mellitus QTL 3

Rattus norvegicus

Klöting, I. et al., Klöting, I. et al., Klöting, I. et al.

Klöting, van den Brandt, Klöting, Radović,

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Disease relevance of Iddm3

Independent crossing studies have demonstrated that diabetes in the BB rat is explained by at least three recessively acting genes termed Iddm1 (major histocompatibility complex), Iddm2 (lymphopenia), Iddm3 (unknown) [1].

High impact information on Iddm3

Using diabetic BB/OK and diabetes-resistant DA rats it has been shown that a third non-MHC gene, Iddm3, on chromosome 18 cosegregates with diabetes in the BB/OK rat subline [2].

Biological context of Iddm3

The percentage of diabetics in Iddm1 and Iddm2 homozygotes confirmed the existence of the third gene, Iddm3, but there were some sex differences; significantly more male than female BC1W-F and significantly more BC1DA-M than BC1DA-F males were diabetic [3].

References

Alleles of diabetes-resistant BN rats contribute to insulin-dependent type 1 diabetes mellitus. Klöting, I., van den Brandt, J., Klöting, N., Radović, B. J. Autoimmun. (2003) [Pubmed]
Mapping of novel genes predisposing or protecting diabetes development in the BB/OK rat. Klöting, I., Schmidt, S., Kovacs, P. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
Crosses between diabetic BB/OK and wild rats confirm that a third gene is essential for diabetes development. Klöting, I., Kovacs, P. Acta diabetologica. (1998) [Pubmed]

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