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Iddm2  -  Insulin dependent diabetes mellitus QTL 2

Rattus norvegicus

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Disease relevance of Iddm2


High impact information on Iddm2


Biological context of Iddm2


Other interactions of Iddm2

  • It is supposed that diabetes protective genes of SHR must be located on both chromosomal segments and that these suppress the action of the essential and most important genes of diabetes development in the BB/OK rat, Iddm1, and Iddm2 [5].


  1. Mapping of novel genes predisposing or protecting diabetes development in the BB/OK rat. Klöting, I., Schmidt, S., Kovacs, P. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  2. Alleles of diabetes-resistant BN rats contribute to insulin-dependent type 1 diabetes mellitus. Klöting, I., van den Brandt, J., Klöting, N., Radović, B. J. Autoimmun. (2003) [Pubmed]
  3. Endocrine pancreas histology of congenic BB-rat strains with reduced diabetes incidence after genetic manipulation on chromosomes 4, 6 and X. Lucke, S., Klöting, I., Pusch, A., Heinrich, H.W., Hahn, H.J. Autoimmunity (2003) [Pubmed]
  4. Crosses between diabetic BB/OK and wild rats confirm that a third gene is essential for diabetes development. Klöting, I., Kovacs, P. Acta diabetologica. (1998) [Pubmed]
  5. Genes of SHR rats protect spontaneously diabetic BB/OK rats from diabetes: lessons from congenic BB.SHR rat strains. Klöting, I., van den Brandt, J., Kuttler, B. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
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