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MeSH Review

Rats, Inbred BB

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Disease relevance of Rats, Inbred BB


High impact information on Rats, Inbred BB


Chemical compound and disease context of Rats, Inbred BB


Biological context of Rats, Inbred BB


Anatomical context of Rats, Inbred BB

  • We observed that BB rat fetal liver cells injected into irradiated scid mice establish a rat hemopoietic system in the scid mouse bone marrow and populate the scid mouse thymus [19].
  • At the onset of diabetes, both streptozotocin-treated and diabetes-prone BB rats exhibited numerous class II positive islet cells that presented ultrastructural features of monocytes and were surrounded by class II negative islet B cells [20].
  • We now report that low-dose irradiation permits the engraftment of BB rat fetal liver stem cells in scid recipients [19].
  • The relative steady-state mRNA levels of the RT1.D alpha and RT1.D beta genes, but not of the RT1.B beta gene, were elevated approximately 2.5-fold in lymphocytes of prediabetic BB rats 45-75 days old in comparison with age-matched normal WF rats and older BB rats greater than 75 days old [21].
  • In contrast, there was no significant decrease in the VMAT2-positive fiber area in the exocrine pancreas in these early diabetic BB rats [22].

Associations of Rats, Inbred BB with chemical compounds


Gene context of Rats, Inbred BB


Analytical, diagnostic and therapeutic context of Rats, Inbred BB


  1. Autoantibodies to a 64-kilodalton islet cell protein precede the onset of spontaneous diabetes in the BB rat. Baekkeskov, S., Dyrberg, T., Lernmark, A. Science (1984) [Pubmed]
  2. IL-1 beta modulation of spontaneous autoimmune diabetes and thyroiditis in the BB rat. Wilson, C.A., Jacobs, C., Baker, P., Baskin, D.G., Dower, S., Lernmark, A., Toivola, B., Vertrees, S., Wilson, D. J. Immunol. (1990) [Pubmed]
  3. Time course of islet cell antibodies in diabetic and nondiabetic BB rats. Laborie, C., Sai, P., Feutren, G., Debray-Sachs, M., Quiniou-Debrie, M.C., Poussier, P., Marliss, E.B., Assan, R. Diabetes (1985) [Pubmed]
  4. Cyclophosphamide inhibits the development of diabetes in the diabetes-prone BB rat. Sobel, D.O., Ahvazi, B., Jun, H.S., Chung, Y.H., Yoon, J.W. Diabetologia (2000) [Pubmed]
  5. Reversal of sensorimotor gating deficits in Brattleboro rats by acute administration of clozapine and a neurotensin agonist, but not haloperidol: a potential predictive model for novel antipsychotic effects. Feifel, D., Melendez, G., Shilling, P.D. Neuropsychopharmacology (2004) [Pubmed]
  6. Immunology of insulin-dependent diabetes mellitus. Rossini, A.A., Mordes, J.P., Like, A.A. Annu. Rev. Immunol. (1985) [Pubmed]
  7. Islet expression of interferon-alpha precedes diabetes in both the BB rat and streptozotocin-treated mice. Huang, X., Hultgren, B., Dybdal, N., Stewart, T.A. Immunity (1994) [Pubmed]
  8. Human HLA-DR beta gene hypervariable region homology in the biobreeding BB rat: selection of the diabetic-resistant subline as a rheumatoid arthritis research tool to characterize the immunopathologic response to human type II collagen. Watson, W.C., Thompson, J.P., Terato, K., Cremer, M.A., Kang, A.H. J. Exp. Med. (1990) [Pubmed]
  9. Immune dysfunction in diabetes-prone BB rats. Interleukin 2 production and other mitogen-induced responses are suppressed by activated macrophages. Prud'homme, G.J., Fuks, A., Colle, E., Seemayer, T.A., Guttmann, R.D. J. Exp. Med. (1984) [Pubmed]
  10. Cyclosporin prevents diabetes in BB Wistar rats. Laupacis, A., Stiller, C.R., Gardell, C., Keown, P., Dupre, J., Wallace, A.C., Thibert, P. Lancet (1983) [Pubmed]
  11. AICAR and phlorizin reverse the hypoglycemia-specific defect in glucagon secretion in the diabetic BB rat. McCrimmon, R.J., Evans, M.L., Jacob, R.J., Fan, X., Zhu, Y., Shulman, G.I., Sherwin, R.S. Am. J. Physiol. Endocrinol. Metab. (2002) [Pubmed]
  12. Polymorphism in gene coding for ACE determines different development of myocardial fibrosis in rats. Ocaranza, M.P., Díaz-Araya, G., Carreño, J.E., Muñoz, D., Riveros, J.P., Jalil, J.E., Lavandero, S. Am. J. Physiol. Heart Circ. Physiol. (2004) [Pubmed]
  13. Prevention of diabetes and induction of non-specific suppressor cell activity in the BB rat by an immunomodulatory azaspirane, SK&F 106610. Rabinovitch, A., Suarez, W.L., Qin, H.Y., Power, R.F., Badger, A.M. J. Autoimmun. (1993) [Pubmed]
  14. Polygenic nature of spontaneous diabetes in the rat. Permissive MHC haplotype and presence of the lymphopenic trait of the BB rat are not sufficient to produce susceptibility. Colle, E., Fuks, A., Poussier, P., Edouard, P., Guttmann, R.D. Diabetes (1992) [Pubmed]
  15. Autoantibodies in nonobese diabetic mice immunoprecipitate 64,000-Mr islet antigen. Atkinson, M.A., Maclaren, N.K. Diabetes (1988) [Pubmed]
  16. Cytokine gene expression in islets and thyroids of BB rats. IFN-gamma and IL-12p40 mRNA increase with age in both diabetic and insulin-treated nondiabetic BB rats. Zipris, D., Greiner, D.L., Malkani, S., Whalen, B., Mordes, J.P., Rossini, A.A. J. Immunol. (1996) [Pubmed]
  17. Diabetic autonomic neuropathy in BB rats and effect of ARI treatment on heart-rate variability and vagus nerve structure. Zhang, W.X., Chakrabarti, S., Greene, D.A., Sima, A.A. Diabetes (1990) [Pubmed]
  18. Antigen activation rescues recent thymic emigrants from programmed cell death in the BB rat. Ramanathan, S., Norwich, K., Poussier, P. J. Immunol. (1998) [Pubmed]
  19. Recapitulation of normal and abnormal BB rat immune system development in scid mouse/rat lymphohemopoietic chimeras. Greiner, D.L., Shultz, L.D., Rossini, A.A., Mordes, J.P., Handler, E.S., Rajan, T.V. J. Clin. Invest. (1991) [Pubmed]
  20. In situ analysis of pancreatic islets in rats developing diabetes. Appearance of nonendocrine cells with surface MHC class II antigens and cytoplasmic insulin immunoreactivity. In't Veld, P.A., Pipeleers, D.G. J. Clin. Invest. (1988) [Pubmed]
  21. Elevated mRNA levels of major histocompatibility complex class II genes in lymphocytes of autoimmune BB rats. Holowachuk, E.W., Greer, M.K., Martin, D.R. Diabetes (1988) [Pubmed]
  22. Early, selective, and marked loss of sympathetic nerves from the islets of BioBreeder diabetic rats. Mei, Q., Mundinger, T.O., Lernmark, A., Taborsky, G.J. Diabetes (2002) [Pubmed]
  23. Reduced beta-cell glucose transporter in new onset diabetic BB rats. Orci, L., Unger, R.H., Ravazzola, M., Ogawa, A., Komiya, I., Baetens, D., Lodish, H.F., Thorens, B. J. Clin. Invest. (1990) [Pubmed]
  24. Prevention of diabetes mellitus in BB rats by neonatal stimulation of beta cells. Buschard, K., Jørgensen, M., Aaen, K., Bock, T., Josefsen, K. Lancet (1990) [Pubmed]
  25. Metabolism of palmitate in isolated working hearts from spontaneously diabetic "BB" Wistar rats. Lopaschuk, G.D., Tsang, H. Circ. Res. (1987) [Pubmed]
  26. Decreased adrenal medullary catecholamine release in spontaneously diabetic BB-Wistar rats. Role of hypoglycemia. Wilke, R.A., Hillard, C.J. Diabetes (1994) [Pubmed]
  27. Regulation of carnitine palmitoyltransferase synthesis in spontaneously diabetic BB Wistar rats. Brady, L.J., Brady, P.S. Diabetes (1989) [Pubmed]
  28. Downregulation of renal aquaporins in response to unilateral ureteral obstruction. Li, C., Wang, W., Knepper, M.A., Nielsen, S., Frøkiaer, J. Am. J. Physiol. Renal Physiol. (2003) [Pubmed]
  29. Aldosterone increases urine production and decreases apical AQP2 expression in rats with diabetes insipidus. Nielsen, J., Kwon, T.H., Praetorius, J., Frøkiaer, J., Knepper, M.A., Nielsen, S. Am. J. Physiol. Renal Physiol. (2006) [Pubmed]
  30. Alleles of diabetes-resistant BN rats contribute to insulin-dependent type 1 diabetes mellitus. Klöting, I., van den Brandt, J., Klöting, N., Radović, B. J. Autoimmun. (2003) [Pubmed]
  31. Role of the thymus in the development of tolerance and autoimmunity towards the neuroendocrine system. Geenen, V., Brilot, F. Ann. N. Y. Acad. Sci. (2003) [Pubmed]
  32. Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice. Campbell, I.L., Kay, T.W., Oxbrow, L., Harrison, L.C. J. Clin. Invest. (1991) [Pubmed]
  33. Prevention of autoimmune islet allograft destruction by engraftment of donor T cells. Bartlett, S.T., Schweitzer, E.J., Kuo, P.C., Johnson, L.B., Delatorre, A., Hadley, G.A. Transplantation (1997) [Pubmed]
  34. Transcription and translation of inducible nitric oxide synthase in the pancreas of prediabetic BB rats. Kleemann, R., Rothe, H., Kolb-Bachofen, V., Xie, Q.W., Nathan, C., Martin, S., Kolb, H. FEBS Lett. (1993) [Pubmed]
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