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Gene Review

scu  -  scully

Drosophila melanogaster

Synonyms: 17-beta-HSD 10, 17-beta-hydroxysteroid dehydrogenase 10, 17beta-HSD10, 3-hydroxy-2-methylbutyryl-CoA dehydrogenase, 3-hydroxyacyl-CoA dehydrogenase type II, ...
 
 
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High impact information on scu

  • The expression of scully mRNA is general to many tissues including the CNS; however, it is highest in both embryonic gonadal primordia and mature ovaries and testes [1].
  • Consistent with this pattern, the phenotypic analysis suggests a role for scully in germ line formation: mutant testis are reduced in size and devoid of maturing sperm, and mutant ovarioles are not able to produce viable eggs [1].
  • The characterization of scully, an essential gene of Drosophila with phenocritical phases at embryonic and pupal stages, shows its extensive homology with vertebrate type II L-3-hydroxyacyl-CoA dehydrogenase/ERAB [1].
  • Confocal microscopy and electron microscopy studies reveal that the human form is localized to mitochondria, whereas Drosophila 17beta-HSD10 shows a cytosolic localization pattern, possibly due to an N-terminal sequence difference that in human 17beta-HSD10 constitutes a mitochondrial targeting signal, extending into the Rossmann-fold motif [2].
 

Analytical, diagnostic and therapeutic context of scu

  • The presence of Rel members in fish implied by those results was confirmed by RT-PCR cloning of a Rel homology domain (an apparent c-rel) from scup liver [3].

References

  1. scully, an essential gene of Drosophila, is homologous to mammalian mitochondrial type II L-3-hydroxyacyl-CoA dehydrogenase/amyloid-beta peptide-binding protein. Torroja, L., Ortuño-Sahagún, D., Ferrús, A., Hämmerle, B., Barbas, J.A. J. Cell Biol. (1998) [Pubmed]
  2. Expanded substrate screenings of human and Drosophila type 10 17beta-hydroxysteroid dehydrogenases (HSDs) reveal multiple specificities in bile acid and steroid hormone metabolism: characterization of multifunctional 3alpha/7alpha/7beta/17beta/20beta/21-HSD. Shafqat, N., Marschall, H.U., Filling, C., Nordling, E., Wu, X.Q., Björk, L., Thyberg, J., Mårtensson, E., Salim, S., Jörnvall, H., Oppermann, U. Biochem. J. (2003) [Pubmed]
  3. Identification of NF-kappaB in the marine fish Stenotomus chrysops and examination of its activation by aryl hydrocarbon receptor agonists. Schlezinger, J.J., Blickarz, C.E., Mann, K.K., Doerre, S., Stegeman, J.J. Chem. Biol. Interact. (2000) [Pubmed]
 
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