Gene Review:
Cpa6 - carboxypeptidase A6
Mus musculus
Synonyms:
9030616D13Rik, Carboxypeptidase A6
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Disease relevance of Cpa6
- The presence of CPA6 mRNA in the rectus muscle layer of the eye at embryonic day 14.5 is consistent with the observation that the CPA6 gene is disrupted in a patient with Duane syndrome, a congenital eye defect [1].
High impact information on Cpa6
- To gain information regarding the potential function of this novel protein, the mouse homolog of CPA6 was identified using a combination of bioinformatics and reverse transcriptase-polymerase chain reaction (RT-PCR) [1].
- Carboxypeptidase A-6 (CPA6) was recently discovered in the human genome [1].
- The distribution was also examined in whole embryos at embryonic day 14.5 and CPA6 mRNA was found to be enriched in eye, ear, osteoblasts, stomach, skin, dorsal root ganglia, and throughout the CNS [1].
- Lower levels of CPA6 mRNA were found to be present in the cingulate cortex, lateral septum, pontine nucleus, and inferior olivary nucleus of the hindbrain [1].
- Taken together, the distribution of CPA6 suggests a specific role in a limited number of tissues, and it is possible that this role involves an aspect of cell migration [1].
Analytical, diagnostic and therapeutic context of Cpa6
- The distribution of CPA6 mRNA in mouse tissues was examined using RT-PCR and in situ hybridization [1].
References
- Identification and distribution of mouse carboxypeptidase A-6. Fontenele-Neto, J.D., Kalinina, E., Feng, Y., Fricker, L.D. Brain Res. Mol. Brain Res. (2005) [Pubmed]
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