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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

dod  -  dodo

Drosophila melanogaster

Synonyms: CG17051, Dmel\CG17051, PPIase dodo, Pin1, Rotamase dodo
 
 
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High impact information on dod

  • Pin1 targets the proline residue carboxy-terminal to the phosphorylated threonine or serine residue, which constitutes part of the phosphorylated mitogen-activated protein kinase (MAPK) site PXpT/SP [1].
  • Drosophila Pin1 prolyl isomerase Dodo is a MAP kinase signal responder during oogenesis [1].
  • The mammalian cis-trans prolyl isomerase Pin1 and its yeast orthologue Ess1/Ptf1 have been implicated in cell cycle control but a correlation between biochemical and physiological functions has not been established conclusively [1].
  • Here we show that the Drosophila Pin1 homologue, the Dodo protein, is involved in dorsoventral patterning of the follicular epithelium in the egg chamber [1].
  • The dodo gene family encodes a novel protein involved in signal transduction and protein folding [2].

References

  1. Drosophila Pin1 prolyl isomerase Dodo is a MAP kinase signal responder during oogenesis. Hsu, T., McRackan, D., Vincent, T.S., Gert de Couet, H. Nat. Cell Biol. (2001) [Pubmed]
  2. The dodo gene family encodes a novel protein involved in signal transduction and protein folding. Maleszka, R., Lupas, A., Hanes, S.D., Miklos, G.L. Gene (1997) [Pubmed]
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