High impact information on Pph13

• Mutation of the photoreceptor specific homeodomain gene Pph13 results in defects in phototransduction and rhabdomere morphogenesis [1].
• In agreement with its expression profile, we find Pph13 is required for both rhabdomere morphogenesis and for the proper detection of light [1].
• Munster, a novel paired-class homeobox gene specifically expressed in the Drosophila larval eye [2].
• Munster (Mu) is a homeobox-containing gene of the Paired-class which is specifically expressed in the developing Bolwig organs, the Drosophila larval eyes [2].
• Strikingly, the Munster gene maps within 6 kb of D-goosecoid, in the same genomic region as aristaless, suggesting that these genes are part of a homeobox gene cluster [2].

Biological context of Pph13

• In addition, we demonstrate that Pph13 exerts its effect by the regulation of photoreceptor specific gene expression [1].

Anatomical context of Pph13

• Pph13 is a homeodomain transcription factor expressed only in photoreceptor cells [1].

References