High impact information on oho23B

• Down-regulation of RpS21, a putative translation initiation factor interacting with P40, produces viable minute imagos and larval lethality with overgrown hematopoietic organs and imaginal discs [1].
• Here, we show that the S21 protein (RpS21) is bound to native 40S ribosomal subunits in a salt-labile association and is absent from polysomes, indicating that it acts as a translation initiation factor rather than as a core ribosomal protein [1].
• Mutations in the RpS21 gene cause dominant Minute and recessive lethal tumorous phenotypes in Drosophila melanogaster [2].
• DNA blot hybridization indicated the existence of a single RpS21 gene in the Ceratitis capitata genome [2].
• Studies in several organisms suggest that RpS21 is involved in the regulation of protein synthesis and cell growth [2].

Analytical, diagnostic and therapeutic context of oho23B

• In this report, we used an RT-PCR fragment of D. melanogaster RpS21 mRNA to clone a RpS21 cDNA from the Mediterranean fruit fly, Ceratitis capitata [2].

References