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Gene Review:

Cf2 - Chorion factor 2

Drosophila melanogaster

Synonyms: BcDNA:GM09668, CF2, CF2.5, CG11924, Chorion transcription factor Cf2, ...

Mantrova, E.Y. et al., Bagni, C. et al., Shea, M.J. et al., Hsu, T. et al., Gogos, J.A. et al., et al.

Bagni, Bray, Gogos, Kafatos, Hsu,

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High impact information on Cf2

Transcripts encoding the Drosophila putative transcription factor CF2 are subject to developmentally regulated alternative splicing, and they encode protein isoforms that differ in the number of zinc fingers [1].
Two major developmentally regulated isoforms of the Drosophila chorion transcription factor CF2 differ by an extra zinc finger within the DNA binding domain [2].
Expression of CF2 itself is negatively regulated by the activated Egfr [3].
The zinc-finger transcription factor CF2 is a negative regulator of the rhomboid (rho) gene that encodes an essential membrane-bound component of the dorsalizing pathway [3].
In this report, we demonstrate that CF2 is the target of down-regulation by the MAPK kinase cascade, and that this down-regulation is independent of the Rho function [3].

Biological context of Cf2

We show that the zinc finger transcription factor CF2 participates in these processes [4].
Furthermore, we show that CF2 down-regulation occurs at the post-translational level through a mechanism involving coupled cytoplasmic retention and degradation [3].
Down-regulation of transcription factor CF2 by Drosophila Ras/MAP kinase signaling in oogenesis: cytoplasmic retention and degradation [3].
DNA sequence analysis suggests that both CF1 and CF2 are novel Drosophila transcription factors [5].
The Drosophila zinc finger transcription factor CF2 is a myogenic marker downstream of MEF2 during muscle development [6].

Anatomical context of Cf2

Here we show that CF2 is also expressed in the developing muscles of the embryo where it first appears at stage 12 at the time of skeletal myoblast fusion [6].

Associations of Cf2 with chemical compounds

CF2 is a member of the C2H2 family of zinc finger proteins, whereas CF1 is a member of the family of steroid hormone receptors [5].

Other interactions of Cf2

These results suggest that D/V patterning involves a two-step signaling process: the initial Egfr signal, which represses CF2 and induces rho expression; and the subsequent Egfr + Rho signal, which determines the dorsal cell fates [3].

References

Multiple zinc finger forms resulting from developmentally regulated alternative splicing of a transcription factor gene. Hsu, T., Gogos, J.A., Kirsh, S.A., Kafatos, F.C. Science (1992) [Pubmed]
Sequence discrimination by alternatively spliced isoforms of a DNA binding zinc finger domain. Gogos, J.A., Hsu, T., Bolton, J., Kafatos, F.C. Science (1992) [Pubmed]
Down-regulation of transcription factor CF2 by Drosophila Ras/MAP kinase signaling in oogenesis: cytoplasmic retention and degradation. Mantrova, E.Y., Hsu, T. Genes Dev. (1998) [Pubmed]
The transcriptional factor CF2 is a mediator of EGF-R-activated dorsoventral patterning in Drosophila oogenesis. Hsu, T., Bagni, C., Sutherland, J.D., Kafatos, F.C. Genes Dev. (1996) [Pubmed]
Proteins that bind to Drosophila chorion cis-regulatory elements: a new C2H2 zinc finger protein and a C2C2 steroid receptor-like component. Shea, M.J., King, D.L., Conboy, M.J., Mariani, B.D., Kafatos, F.C. Genes Dev. (1990) [Pubmed]
The Drosophila zinc finger transcription factor CF2 is a myogenic marker downstream of MEF2 during muscle development. Bagni, C., Bray, S., Gogos, J.A., Kafatos, F.C., Hsu, T. Mech. Dev. (2002) [Pubmed]

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