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Gene Review:

nad5 - NADH dehydrogenase subunit 5

Arabidopsis thaliana

Pereira de Souza, A. et al., Knoop, V. et al., Knoop, V. et al., Brandt, P. et al.

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High impact information on nad5

The genes coding for NADH dehydrogenase subunit 5 (nad5) in mitochondria of the higher plants Oenothera and Arabidopsis are split into five exons that are located in three distant genomic regions [1].
In mitochondria of flowering plants the nad5 open reading frame is assembled from five exons via two conventional cis-splicing and two trans-splicing events [2].
The physical proximity of these genes further supports the trans-splicing model for assembly of the nad5 mRNA [3].
Transcription analysis of the nad5 gene in chicory and in cauliflower shows that the five exons are assembled as a mature mRNA through intermolecular interactions and multiple splicing events [4].
The single copy nad5 gene has been identified in the mitochondrial genomes of cauliflower, chicory, potato, fennel, and common bean [4].

Biological context of nad5

Trans splicing integrates an exon of 22 nucleotides into the nad5 mRNA in higher plant mitochondria [1].
The higher plant nad5 mitochondrial gene: a conserved discontinuous transcription pattern [4].

References

Trans splicing integrates an exon of 22 nucleotides into the nad5 mRNA in higher plant mitochondria. Knoop, V., Schuster, W., Wissinger, B., Brennicke, A. EMBO J. (1991) [Pubmed]
A tripartite group II intron in mitochondria of an angiosperm plant. Knoop, V., Altwasser, M., Brennicke, A. Mol. Gen. Genet. (1997) [Pubmed]
The nad4L gene is encoded between exon c of nad5 and orf25 in the Arabidopsis mitochondrial genome. Brandt, P., Sünkel, S., Unseld, M., Brennicke, A., Knoop, V. Mol. Gen. Genet. (1992) [Pubmed]
The higher plant nad5 mitochondrial gene: a conserved discontinuous transcription pattern. Pereira de Souza, A., Jubier, M.F., Lejeune, B. Curr. Genet. (1992) [Pubmed]

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