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Gene Review:

LOC338400 - von Ebner's-like protein

Rattus norvegicus

Syed, V. et al., Syed, V. et al.

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Psychiatry related information on LOC338400

mRNAs encoding a von Ebner's-like protein and the Huntington disease protein are induced in rat male germ cells by Sertoli cells [1].

High impact information on LOC338400

The von Ebner's-like protein was induced in germ cells by a secreted Sertoli cell factor(s) smaller than 10 kDa that is sensitive to freezing and thawing or boiling [1].
One marker, a von Ebner's-like protein, is expressed in coculture and "in vivo" in germ cells from normal testes of 6- and 24-mo-old rats but not in germ cells from regressed testes of 24-mo-old rats [2].

Analytical, diagnostic and therapeutic context of LOC338400

The von Ebner's-like protein mRNA was induced after 4 h of co-culture, while the Huntington disease protein required 18 h of co-culture for expression [1].

References

mRNAs encoding a von Ebner's-like protein and the Huntington disease protein are induced in rat male germ cells by Sertoli cells. Syed, V., Gomez, E., Hecht, N.B. J. Biol. Chem. (1999) [Pubmed]
Selective loss of Sertoli cell and germ cell function leads to a disruption in sertoli cell-germ cell communication during aging in the Brown Norway rat. Syed, V., Hecht, N.B. Biol. Reprod. (2001) [Pubmed]

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