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Gene Review:

Rca1 - Regulator of cyclin A1

Drosophila melanogaster

Synonyms: 152549_at, CG10800, CLD4, Dmel\CG10800, Emi1, ...

Lear, B.C. et al., Grosskortenhaus, R. et al., Zielke, N. et al., Dong, X. et al., Wai, P. et al.

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Disease relevance of Rca1

In the central nervous system (CNS) of Drosophila embryos lacking regulator of cyclin A (rca1) or cyclin A, we observe that several ganglion mother cells (GMCs) fail to divide [1].

High impact information on Rca1

Expression of rca1 transgenes in G1 or in postmitotic neurons promotes Cyclin A protein accumulation and drives cells into S phase in a Cyclin A-dependent fashion [2].
We report that the loss of cycA, rca1 or stg leads to a block in the division of GMC-1, however, this GMC-1 exclusively adopts an RP2 identity [3].
Conversely, S-phase entry is delayed in cells in which endogenous Rca1 is replaced by a transgene lacking the F-box [4].
Rca1 inhibits APC-Cdh1(Fzr) and is required to prevent cyclin degradation in G2 [5].
Overexpression of Cdh1(Fzr) mimics the rca1 phenotype, and coexpression of Rca1 blocks this Cdh1(Fzr) function [5].

Biological context of Rca1

In rca1 mutants, cyclins are degraded prematurely in G2 by APC-Cdh1(Fzr)-dependent proteolysis, and cells fail to execute mitosis [5].

Anatomical context of Rca1

Neural cell fate in rca1 and cycA mutants: the roles of intrinsic and extrinsic factors in asymmetric division in the Drosophila central nervous system [1].

Analytical, diagnostic and therapeutic context of Rca1

Molecular dissection of the APC/C inhibitor Rca1 shows a novel F-box-dependent function [4].

References

Neural cell fate in rca1 and cycA mutants: the roles of intrinsic and extrinsic factors in asymmetric division in the Drosophila central nervous system. Lear, B.C., Skeath, J.B., Patel, N.H. Mech. Dev. (1999) [Pubmed]
Control of G1 in the developing Drosophila eye: rca1 regulates Cyclin A. Dong, X., Zavitz, K.H., Thomas, B.J., Lin, M., Campbell, S., Zipursky, S.L. Genes Dev. (1997) [Pubmed]
Cell division genes promote asymmetric interaction between Numb and Notch in the Drosophila CNS. Wai, P., Truong, B., Bhat, K.M. Development (1999) [Pubmed]
Molecular dissection of the APC/C inhibitor Rca1 shows a novel F-box-dependent function. Zielke, N., Querings, S., Grosskortenhaus, R., Reis, T., Sprenger, F. EMBO Rep. (2006) [Pubmed]
Rca1 inhibits APC-Cdh1(Fzr) and is required to prevent cyclin degradation in G2. Grosskortenhaus, R., Sprenger, F. Dev. Cell (2002) [Pubmed]

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