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Gene Review:

tubB - beta tubulin

Dictyostelium discoideum AX4

Triviños-Lagos, L. et al., White, E. et al., Noegel, A.A. et al.

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High impact information on tubB

Southern blot analysis suggests that Dictyostelium is unusual in that its genome contains single alpha- and beta-tubulin genes, rather than the multi-gene family common in most eukaryotic organisms [1].
These antisera recognize one alpha- and two beta-tubulin spots on western blots of 2-D gels and, by indirect immunofluorescence, both recognize the interphase and mitotic microtubule arrays in vegetative amoebae [1].
Methods have been developed for analyzing tubulin and microtubules from the cellular slime mold D. discoideum. alpha- and beta-tubulin have been identified on high-resolution 2D gels, and microtubules have been isolated in cytoskeleton preparations from amoebae (White et al., 1983) [2].
New avenues of cytoskeleton research in Dictyostelium discoideum have opened up with the cloning of the alpha- and beta-tubulin genes and the characterization of kinesins and cytoplasmic dynein [3].

Analytical, diagnostic and therapeutic context of tubB

Single alpha- and beta-tubulin transcripts are detected by northern blot analysis during all stages of Dictyostelium development [1].

References

The highly divergent alpha- and beta-tubulins from Dictyostelium discoideum are encoded by single genes. Triviños-Lagos, L., Ohmachi, T., Albrightson, C., Burns, R.G., Ennis, H.L., Chisholm, R.L. J. Cell. Sci. (1993) [Pubmed]
Biochemical and genetic approaches to microtubule function in Dictyostelium discoideum. White, E., Katz, E.R. Methods Cell Biol. (1987) [Pubmed]
The Dictyostelium cytoskeleton. Noegel, A.A., Luna, J.E. Experientia (1995) [Pubmed]

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