Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

blaA - class-A beta-lactamase

Pseudomonas aeruginosa

Matsumoto, Y. et al., Monks, J. et al., Naas, T. et al., Lim, D. et al., Poirel, L. et al.

Matsumoto, Inoue,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of blaA

Characterization of SFO-1, a plasmid-mediated inducible class A beta-lactamase from Enterobacter cloacae [1].
PSE-4 is a class A beta-lactamase produced by strains of Pseudomonas aeruginosa and is highly active for the penicillin derivative carbenicillin [2].
This is the first report from Japan describing an inducible plasmid-mediated class A beta-lactamase in gram-negative bacteria [1].
Serratia marcescens S6 produces a chromosomally encoded carbapenem-hydrolyzing class A beta-lactamase, Sme-1 (T. Naas, L. Vandel, W. Sougakoff, D. M. Livermore, and P. Nordmann, Antimicrob. Agents Chemother. 38:1262-1270, 1994) [3].
The first enzyme was beta-lactamase I, a class-A beta-lactamase from Bacillus cereus; imipenem behaved as a slow substrate (kcat. 6.7 min-1, Km 0.4 mM at 30 degrees C and at pH 7) that reacted by a branched pathway [4].

High impact information on blaA

GES-2, a class A beta-lactamase from Pseudomonas aeruginosa with increased hydrolysis of imipenem [5].
Enterobacter cloacae 8009 produced an inducible class A beta-lactamase which hydrolyzed cefotaxime efficiently [1].

References

Characterization of SFO-1, a plasmid-mediated inducible class A beta-lactamase from Enterobacter cloacae. Matsumoto, Y., Inoue, M. Antimicrob. Agents Chemother. (1999) [Pubmed]
Insights into the molecular basis for the carbenicillinase activity of PSE-4 beta-lactamase from crystallographic and kinetic studies. Lim, D., Sanschagrin, F., Passmore, L., De Castro, L., Levesque, R.C., Strynadka, N.C. Biochemistry (2001) [Pubmed]
Characterization of an LysR family protein, SmeR from Serratia marcescens S6, its effect on expression of the carbapenem-hydrolyzing beta-lactamase Sme-1, and comparison of this regulator with other beta-lactamase regulators. Naas, T., Livermore, D.M., Nordmann, P. Antimicrob. Agents Chemother. (1995) [Pubmed]
Imipenem as substrate and inhibitor of beta-lactamases. Monks, J., Waley, S.G. Biochem. J. (1988) [Pubmed]
GES-2, a class A beta-lactamase from Pseudomonas aeruginosa with increased hydrolysis of imipenem. Poirel, L., Weldhagen, G.F., Naas, T., De Champs, C., Dove, M.G., Nordmann, P. Antimicrob. Agents Chemother. (2001) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.