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Chemical Compound Review

AGN-PC-00JWDR     6-[(2-carboxy-2-phenyl- ethanoyl)amino]-3,3...

Synonyms: SureCN11310979, Oprea1_556099, AKOS015966636, AC1L1DY8, NCI60_000253
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Disease relevance of carbenicillin


High impact information on carbenicillin


Chemical compound and disease context of carbenicillin


Biological context of carbenicillin


Anatomical context of carbenicillin

  • We found that beta-lactamase fusion proteins carrying a eukaryotic signal peptide at its N-terminus were able to direct their export into the periplasm in E. coli to confer survival upon challenge with carbenicillin [18].
  • One hundred seven patients were treated with either piperacillin (56) or carbenicillin (51) in an open randomized trial of hospitalized patients with pleuropulmonary (40), urinary tract (26), gynecologic (21), skin and soft-tissue (eight), joint (five), bone (three), and miscellaneous other infections (four) [19].
  • This killing was shown to be unaffected by treatment with carbenicillin, an inhibitor of bacterial cell wall biosynthesis and, indirectly, replication [20].
  • The intrinsic-resistance phenotype becomes further enhanced in "intrinsically carbenicillin-resistant" isolates, which were often assumed to produce outer membranes of even lower permeability [21].
  • In the first study, corneas still contained Pseudomonas after 4 days of continual topical therapy with either tobramycin 400 mg/ml, amikacin 250 mg/ml, ticarcillin 400 mg/ml, or carbenicillin 400 mg/ml [22].

Associations of carbenicillin with other chemical compounds


Gene context of carbenicillin


Analytical, diagnostic and therapeutic context of carbenicillin


  1. Carbenicillin-associated hypokalemic alkalosis. Cabizuca, S.V., Desser, K.B. JAMA (1976) [Pubmed]
  2. Antagonism of the antibacterial action of some penicillins by other penicillins and cephalosporins. Acar, J.F., Sabath, L.D., Ruch, P.A. J. Clin. Invest. (1975) [Pubmed]
  3. Aerosol carbenicillin and gentamicin treatment of Pseudomonas aeruginosa infection in patients with cystic fibrosis. Hodson, M.E., Penketh, A.R., Batten, J.C. Lancet (1981) [Pubmed]
  4. Carbenicillin-induced haemorrhagic cystitis. Møller, N.E. Lancet (1978) [Pubmed]
  5. Carbenicillin and pseudomembranous enterocolitis. O'Meara, T.F., Simmons, R.A. Ann. Intern. Med. (1980) [Pubmed]
  6. Oral ciprofloxacin therapy of infections due to Pseudomonas aeruginosa. Scully, B.E., Neu, H.C., Parry, M.F., Mandell, W. Lancet (1986) [Pubmed]
  7. Invasive aspergillosis in acute leukemia: correlation with nose cultures and antibiotic use. Aisner, J., Murillo, J., Schimpff, S.C., Steere, A.C. Ann. Intern. Med. (1979) [Pubmed]
  8. Transformation of Pseudomonas putida and Escherichia coli with plasmid-linked drug-resistance factor DNA. Chakrabarty, A.M., Mylroie, J.R., Friello, D.A., Vacca, J.G. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  9. Experimental Pseudomonas pneumonia in leukopenic dogs: comparison of therapy with antibiotics and granulocyte transfusions. Dale, D.C., Reynolds, H.Y., Pennington, J.E., Elin, R.J., Herzig, G.P. Blood (1976) [Pubmed]
  10. Infection in patients with cystic fibrosis. Rubio, T.T. Am. J. Med. (1986) [Pubmed]
  11. Clinical evaluation of piperacillin therapy for infection. Pancoast, S., Prince, A.S., Francke, E.L., Neu, H.C. Arch. Intern. Med. (1981) [Pubmed]
  12. Use of cefotaxime, a beta-lactamase stable cephalosporin, in the therapy of serious infections, including those due to multiresistant organisms. Francke, E.L., Neu, H.C. Am. J. Med. (1981) [Pubmed]
  13. Pseudomonas bacteremia. Review of 108 cases. Flick, M.R., Cluff, L.E. Am. J. Med. (1976) [Pubmed]
  14. Kinetics of mezlocillin and carbenicillin. Pancoast, S.J., Neu, H.C. Clin. Pharmacol. Ther. (1978) [Pubmed]
  15. Ticarcillin vs carbenicillin: clinical pharmacokinetics. Libke, R.D., Clarke, J.T., Ralph, E.D., Luthy, R.P., Kirby, W.M. Clin. Pharmacol. Ther. (1975) [Pubmed]
  16. Pseudomonas aeruginosa strain isolated in France that carries a plasmid determining carbenicillin resistance. Michel-Briand, Y., Stanisich, V.A., Jouvenot, M. Antimicrob. Agents Chemother. (1977) [Pubmed]
  17. Beta-lactamase lability and inducer power of newer beta-lactam antibiotics in relation to their activity against beta-lactamase-inducibility mutants of Pseudomonas aeruginosa. Livermore, D.M., Yang, Y.J. J. Infect. Dis. (1987) [Pubmed]
  18. E. coli selection of human genes encoding secreted and membrane proteins based on cDNA fusions to a leaderless beta-lactamase reporter. Tan, R., Jiang, X., Jackson, A., Jin, P., Yang, J., Lee, E., Duggan, B., Stuve, L.L., Fu, G.K. Genome Res. (2003) [Pubmed]
  19. Piperacillin v Carbenicillin in the therapy for serious infections. Marier, R.L., Sanders, C.V., Faro, S., Janney, A., Williams, W.W., Derks, F., Aldridge, K.E. Arch. Intern. Med. (1982) [Pubmed]
  20. Brucella abortus rough mutants induce macrophage oncosis that requires bacterial protein synthesis and direct interaction with the macrophage. Pei, J., Turse, J.E., Wu, Q., Ficht, T.A. Infect. Immun. (2006) [Pubmed]
  21. Role of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: resistance to tetracycline, chloramphenicol, and norfloxacin. Li, X.Z., Livermore, D.M., Nikaido, H. Antimicrob. Agents Chemother. (1994) [Pubmed]
  22. Bacteriologic cure of experimental Pseudomonas keratitis. Davis, S.D., Sarff, L.D., Hyndiuk, R.A. Invest. Ophthalmol. Vis. Sci. (1978) [Pubmed]
  23. In vivo inactivation of gentamicin by carbenicillin and ticarcillin. Kradjan, W.A., Burger, R. Arch. Intern. Med. (1980) [Pubmed]
  24. Pharmacokinetics of sulbenicillin, a new broad-spectrum semisynthetic penicillin. Hansen, I.B., Jacobsen, E., Weis, J. Clin. Pharmacol. Ther. (1975) [Pubmed]
  25. Roles of amino acids 161 to 179 in the PSE-4 omega loop in substrate specificity and in resistance to ceftazidime. Therrien, C., Sanschagrin, F., Palzkill, T., Levesque, R.C. Antimicrob. Agents Chemother. (1998) [Pubmed]
  26. Animal model distinguishing in vitro from in vivo carbenicillin-aminoglycoside interactions. Pieper, J.A., Vidal, R.A., Schentag, J.J. Antimicrob. Agents Chemother. (1980) [Pubmed]
  27. Characterisation of a unique ceftazidime-hydrolysing beta-lactamase, TEM-E2. Payne, D.J., Marriott, M.S., Amyes, S.G. J. Med. Microbiol. (1990) [Pubmed]
  28. In vitro study of clavulanic acid in combination with penicillin, amoxycillin, and carbenicillin. Wise, R., Andrews, J.M., Bedford, K.A. Antimicrob. Agents Chemother. (1978) [Pubmed]
  29. Beta-lactamase stability of cefoxitin in comparison with other beta-lactam compounds. Neu, H.C. Diagn. Microbiol. Infect. Dis. (1983) [Pubmed]
  30. Sequencing and expression of aadA, bla, and tnpR from the multiresistance transposon Tn1331. Tolmasky, M.E. Plasmid (1990) [Pubmed]
  31. Molecular analysis of regulatory and structural xyl genes of the TOL plasmid pWW53-4. Keil, H., Keil, S., Williams, P.A. J. Gen. Microbiol. (1987) [Pubmed]
  32. Activities of various beta-lactams and aminoglycosides, alone and in combination, against isolates of Pseudomonas aeruginosa from patients with cystic fibrosis. Scribner, R.K., Marks, M.I., Weber, A.H., Tarpay, M.M., Welch, D.F. Antimicrob. Agents Chemother. (1982) [Pubmed]
  33. Comparative study of piperacillin, ticarcillin, and carbenicillin pharmacokinetics. Meyers, B.R., Hirschman, S.Z., Strougo, L., Srulevitch, E. Antimicrob. Agents Chemother. (1980) [Pubmed]
  34. Preparation, hydrolysis, and oral absorption of alpha-carboxy esters of carbenicillin. Clayton, J.P., Cole, M., Elson, S.W., Hardy, K.D., Mizen, L.W., Sutherland, R. J. Med. Chem. (1975) [Pubmed]
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