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Gene Review:

IDDM7 - insulin-dependent diabetes mellitus 7

Homo sapiens

Kristiansen, O.P. et al., Myerscough, A. et al., Iwata, I. et al., Hansen, L. et al., Luo, D.F. et al., et al.

Hansen, Jensen, Urioste, Petersen, Pociot, Eiberg, Kristiansen, Hansen, Serup, Nerup, Pedersen, Iwata, Nagafuchi, Nakashima, Kondo, Koga, Yokogawa, Akashi, Shibuya, Umeno, Okeda, Shibata, Kono, Yasunami, Ohkubo, Niho,

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Disease relevance of IDDM7

The insulin-dependent diabetes mellitus (IDDM) susceptibility locus IDDM7 on 2q31 links to IDDM in some but not other populations [1].

High impact information on IDDM7

Linkage disequilibrium mapping of a type 1 diabetes susceptibility gene (IDDM7) to chromosome 2q31-q33 [2].
However, we could not confirm linkage for IDDM3 on 15q26 and IDDM7 on 2q31-q33, or linkage disequilibrium between D2S152 and IDDM7 [3].
METHODS: Five IDDM susceptibility loci map to 2 chromosomal regions, chromosome 2q31-34 (IDDM7, 12, and 13) and chromosome 6q25-27 (IDDM5 and 8) [4].
There was no evidence for significant linkage disequilibrium of RA with any markers at IDDM7, 12, or 13 [4].
However, in the type 1 diabetic Danish population, the Ala45Thr variant of NeuroD/BETA2 may represent a susceptibility marker independent of IDDM7 on chromosome 2q32 [5].

Biological context of IDDM7

Recently, the NeuroD/BETA2 gene has been mapped to the long arm of human chromosome 2 (2q32) where the IDDM7 gene has previously been mapped, implying its involvement in diabetes [6].

Associations of IDDM7 with chemical compounds

The BETA 2/NEUROD1 gene-locus lies on human chromosome 2q32, in a region previously linked to Type 1 diabetes (IDDM7) [7].

Other interactions of IDDM7

In conclusion, IDDM7 (D2S152) links to IDDM in Danish patients, but D2S2363 and the identified T284A polymorphism in the GALNT3 3'UTR did not [1].

References

IDDM7 links to insulin-dependent diabetes mellitus in Danish multiplex families but linkage is not explained by novel polymorphisms in the candidate gene GALNT3. The Danish Study Group of Diabetes in Childhood and The Danish IDDM Epidemiology and Genetics Group. Kristiansen, O.P., Pociot, F., Bennett, E.P., Clausen, H., Johannesen, J., Nerup, J., Mandrup-Poulsen, T. Hum. Mutat. (2000) [Pubmed]
Linkage disequilibrium mapping of a type 1 diabetes susceptibility gene (IDDM7) to chromosome 2q31-q33. Copeman, J.B., Cucca, F., Hearne, C.M., Cornall, R.J., Reed, P.W., Rønningen, K.S., Undlien, D.E., Nisticò, L., Buzzetti, R., Tosi, R. Nat. Genet. (1995) [Pubmed]
Confirmation of three susceptibility genes to insulin-dependent diabetes mellitus: IDDM4, IDDM5 and IDDM8. Luo, D.F., Buzzetti, R., Rotter, J.I., Maclaren, N.K., Raffel, L.J., Nisticò, L., Giovannini, C., Pozzilli, P., Thomson, G., She, J.X. Hum. Mol. Genet. (1996) [Pubmed]
Linkage of rheumatoid arthritis to insulin-dependent diabetes mellitus loci: evidence supporting a hypothesis for the existence of common autoimmune susceptibility loci. Myerscough, A., John, S., Barrett, J.H., Ollier, W.E., Worthington, J. Arthritis Rheum. (2000) [Pubmed]
NeuroD/BETA2 gene variability and diabetes: no associations to late-onset type 2 diabetes but an A45 allele may represent a susceptibility marker for type 1 diabetes among Danes. Danish Study Group of Diabetes in Childhood, and the Danish IDDM Epidemiology and Genetics Group. Hansen, L., Jensen, J.N., Urioste, S., Petersen, H.V., Pociot, F., Eiberg, H., Kristiansen, O.P., Hansen, T., Serup, P., Nerup, J., Pedersen, O. Diabetes (2000) [Pubmed]
Association of polymorphism in the NeuroD/BETA2 gene with type 1 diabetes in the Japanese. Iwata, I., Nagafuchi, S., Nakashima, H., Kondo, S., Koga, T., Yokogawa, Y., Akashi, T., Shibuya, T., Umeno, Y., Okeda, T., Shibata, S., Kono, S., Yasunami, M., Ohkubo, H., Niho, Y. Diabetes (1999) [Pubmed]
Absence of replication in the French population of the association between beta 2/NEUROD-A45T polymorphism and type 1 diabetes. Dupont, S., Dina, C., Hani, E.H., Froguel, P. Diabetes Metab. (1999) [Pubmed]

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