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KCNT2  -  potassium channel, sodium activated...

Homo sapiens

Synonyms: KCa4.2, Potassium channel subfamily T member 2, SLICK, SLO2.1, Sequence like an intermediate conductance potassium channel subunit, ...
 
 
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Disease relevance of KCNT2

 

Psychiatry related information on KCNT2

  • Presented are four patients claiming cognitive deficits after apparent occupational neurotoxic exposure who were diagnosed as malingering using the Slick, Sherman, and Iverson criteria [2].
  • To preserve the fidelity of timing of action potentials that is required for sound localization, these neurons express several types of potassium channels, including the Kv3 and Kv1 families of voltage-dependent channels and the Slick and Slack sodium-dependent channels [3].
  • Estimates were based on two methods: (1) clinical identification using the Slick, Sherman and Iverson criteria for malingered neurocognitive dysfunction (MND), and (2) statistical modeling based on patient performance on several individual psychometric indicators of malingering [4].
 

High impact information on KCNT2

  • Forty-one of 161 TBI patients met Slick, Sherman, and Iverson (1999) criteria for Malingered Neurocognitive Dysfunction [5].
  • Malingered neurocognitive dysfunction in neurotoxic exposure: an application of the Slick criteria [6].
  • The Slick Tracy Home Team Program was the first intervention of Project Northland, a large 3 year community trial of the efficacy of a public health intervention for under age drinking [7].
  • Cross-Cultural Adaptation and Evaluation of a Home-Based Program for Alcohol Use Prevention among Urban Youth: The "Slick Tracy Home Team Program" [8].
 

Analytical, diagnostic and therapeutic context of KCNT2

  • The control group was comprised of 37 patients without external incentive and who thus did not meet the Slick et al. criteria [9].

References

  1. Detecting malingered performance with the Wisconsin card sorting test: a preliminary investigation in traumatic brain injury. Greve, K.W., Bianchini, K.J., Mathias, C.W., Houston, R.J., Crouch, J.A. The Clinical neuropsychologist. (2002) [Pubmed]
  2. Malingered neurocognitive dysfunction in neurotoxic exposure: an application of the Slick criteria. Bianchini, K.J., Houston, R.J., Greve, K.W., Irvin, T.R., Black, F.W., Swift, D.A., Tamimie, R.J. J. Occup. Environ. Med. (2003) [Pubmed]
  3. Regulation of the timing of MNTB neurons by short-term and long-term modulation of potassium channels. Kaczmarek, L.K., Bhattacharjee, A., Desai, R., Gan, L., Song, P., von Hehn, C.A., Whim, M.D., Yang, B. Hear. Res. (2005) [Pubmed]
  4. The prevalence of cognitive malingering in persons reporting exposure to occupational and environmental substances. Greve, K.W., Bianchini, K.J., Black, F.W., Heinly, M.T., Love, J.M., Swift, D.A., Ciota, M. Neurotoxicology (2006) [Pubmed]
  5. Classification accuracy of the test of memory malingering in traumatic brain injury: results of a known-groups analysis. Greve, K.W., Bianchini, K.J., Doane, B.M. Journal of clinical and experimental neuropsychology : official journal of the International Neuropsychological Society. (2006) [Pubmed]
  6. Malingered neurocognitive dysfunction in neurotoxic exposure: an application of the Slick criteria. Morton, W.E. J. Occup. Environ. Med. (2004) [Pubmed]
  7. Russian-American partners for prevention. Adaptation of a school-based parent-child programme for alcohol use prevention. Williams, C.L., Grechanaia, T., Romanova, O., Komro, K.A., Perry, C.L., Farbakhsh, K. European journal of public health. (2001) [Pubmed]
  8. Cross-Cultural Adaptation and Evaluation of a Home-Based Program for Alcohol Use Prevention among Urban Youth: The "Slick Tracy Home Team Program". Komro, K.A., Perry, C.L., Veblen-Mortenson, S., Farbakhsh, K., Kugler, K.C., Alfano, K.A., Dudovitz, B.S., Williams, C.L., Jones-Webb, R. The journal of primary prevention. (2006) [Pubmed]
  9. Detecting malingered performance on the Wechsler Adult Intelligence Scale. Validation of Mittenberg's approach in traumatic brain injury. Greve, K.W., Bianchini, K.J., Mathias, C.W., Houston, R.J., Crouch, J.A. Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists. (2003) [Pubmed]
 
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