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Gene Review:

AOX2P - aldehyde oxidase 2 pseudogene

Homo sapiens

Synonyms: AOH2, AOX2

Ohi, H. et al., Ohi, H. et al., Ngo, S.N. et al., Kuwae, S. et al., Kobayashi, K. et al., et al.

Kuwae, Ohyama, Ohya, Ohi, Kobayashi, Ohi, Okazaki, Uno, Miura, Hiramatsu,

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High impact information on AOX2

AOX2 and AOX3 proteins differ in their ability to be regulated by reversible dimerization [1].
Two 2039 bp koala liver AOX cDNAs, designated AOX1 and AOX2, were cloned by reverse transcription-polymerase chain reaction and rapid amplification of cDNA ends [2].
Thirteen cloned genes isolated from strain GTS115 were assigned to the separated chromosomes, revealing that different hybridization patterns were observed in the AOX2 and URA3 genes among strains [3].
To study the role of cis-acting elements in the promoter region of the AOX2 gene, we constructed expression plasmids in which the human serum albumin (HSA) gene was placed under the control of various deleted or mutated AOX2 promoter derivatives [4].
The positive and negative cis-acting elements for methanol regulation in the Pichia pastoris AOX2 gene [4].

Associations of AOX2 with chemical compounds

However, a deletion mutant that was not lacking an upstream region from the AOX2 promoter showed a response to oleic acid [5].
In the glycerol-limited fed-batch fermentation, rAT is expressed at 100 mg/l under the control of the truncated mutated AOX2 promoter [6].

References

Differential expression of alternative oxidase genes in maize mitochondrial mutants. Karpova, O.V., Kuzmin, E.V., Elthon, T.E., Newton, K.J. Plant Cell (2002) [Pubmed]
Identification and cloning of two forms of liver peroxisomal fatty Acyl CoA Oxidase from the koala (Phascolarctos cinereus). Ngo, S.N., McKinnon, R.A., Stupans, I. Gene (2003) [Pubmed]
Chromosomal DNA patterns and gene stability of Pichia pastoris. Ohi, H., Okazaki, N., Uno, S., Miura, M., Hiramatsu, R. Yeast (1998) [Pubmed]
The positive and negative cis-acting elements for methanol regulation in the Pichia pastoris AOX2 gene. Ohi, H., Miura, M., Hiramatsu, R., Ohmura, T. Mol. Gen. Genet. (1994) [Pubmed]
Addition of oleic acid increases expression of recombinant human serum albumin by the AOX2 promoter in Pichia pastoris. Kobayashi, K., Kuwae, S., Ohya, T., Ohda, T., Ohyama, M., Tomomitsu, K. J. Biosci. Bioeng. (2000) [Pubmed]
Production of recombinant human antithrombin by Pichia pastoris. Kuwae, S., Ohyama, M., Ohya, T., Ohi, H., Kobayashi, K. J. Biosci. Bioeng. (2005) [Pubmed]

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