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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

bun  -  bunched

Drosophila melanogaster

Synonyms: 1550, Bun, BunA, CG31857, CG42281, ...
 
 
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High impact information on bun

  • We also report that the expression of these different shsp raised the total glutathione level in both L929 cell lines and transiently transfected NIH 3T3-ras cells [1].
  • Several downstream effects resulting from the TNFalpha-mediated ROS increment, such as NF-kappaB activation, lipid peroxidation and protein oxidation, were inhibited by shsp expression [1].
  • DPP induces expression of the enhancer trap reporter A359 and represses expression of bunched, which encodes a protein similar to the mammalian transcription factor TSC-22 [2].
  • During Drosophila oogenesis, the long-range signals EGF and Dpp regulate expression of bunched (bun), which encodes a homolog of mammalian transcription factors TSC-22 and GILZ [3].
  • A Drosophila melanogaster sequence homologous to the mammalian growth factor-stimulated TSC-22 gene was isolated in an enhancer trap screen for genes expressed in anterodorsal follicle cells during oogenesis [4].

References

  1. Human hsp27, Drosophila hsp27 and human alphaB-crystallin expression-mediated increase in glutathione is essential for the protective activity of these proteins against TNFalpha-induced cell death. Mehlen, P., Kretz-Remy, C., Préville, X., Arrigo, A.P. EMBO J. (1996) [Pubmed]
  2. Drosophila bunched integrates opposing DPP and EGF signals to set the operculum boundary. Dobens, L.L., Peterson, J.S., Treisman, J., Raftery, L.A. Development (2000) [Pubmed]
  3. Bunched sets a boundary for Notch signaling to pattern anterior eggshell structures during Drosophila oogenesis. Dobens, L., Jaeger, A., Peterson, J.S., Raftery, L.A. Dev. Biol. (2005) [Pubmed]
  4. The Drosophila bunched gene is a homologue of the growth factor stimulated mammalian TSC-22 sequence and is required during oogenesis. Dobens, L.L., Hsu, T., Twombly, V., Gelbart, W.M., Raftery, L.A., Kafatos, F.C. Mech. Dev. (1997) [Pubmed]
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