Gene Review:
Saci_1756 - uracil DNA glycosylase
Sulfolobus acidocaldarius DSM 639
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Disease relevance of Saci_1756
- Uracil-DNA glycosylase inhibitor protein of the Bacillus subtilis bacteriophage PBS1 shows activity against all of these, suggesting a highly conserved tertiary structure between hyperthermophilic and mesophilic uracil-DNA glycosylases [1].
- In this study we have demonstrated the presence of thermally stable uracil-DNA glycosylase activities in seven hyperthermophiles; one bacterial: Thermotoga maritima, and six archaeal: Sulfolobus solfataricus, Sulfolobus shibatae, Sulfolobus acidocaldarius, Thermococcus litoralis, Pyrococcus furiosus and Pyrobaculum islandicum [1].
References
- Uracil-DNA glycosylase activities in hyperthermophilic micro-organisms. Koulis, A., Cowan, D.A., Pearl, L.H., Savva, R. FEMS Microbiol. Lett. (1996) [Pubmed]
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