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Gene Review:

CLIP-190 - Cytoplasmic linker protein 190

Drosophila melanogaster

Synonyms: CG5020, CLIP190, Clip- 190, Clip-190, Clip190, ...

Dzhindzhev, N.S. et al., Lantz, V.A. et al., Máthé, E. et al., Maiato, H. et al.

Lantz, Miller,

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Psychiatry related information on CLIP-190

An inhibitor study also suggested that the motor activity of dynein is required for the removal of CLIP-190 from attached kinetochores [1].

High impact information on CLIP-190

However, loss of MAST/Orbit does not affect the kinetochore localization of D-CLIP-190 [2].
95F myosin and D-CLIP-190 are coexpressed in a number of tissues during embryogenesis in Drosophila [3].
We have named this protein D-CLIP-190 (the predicted molecular mass is 189 kD) based on its similarity to CLIP-170 and its ability to cosediment with microtubules [3].
Another microtubule plus-end tracking protein, EB1, directly interacts with the CAP-Gly domain of CLIP-190 and is required to localise CLIP-190 at microtubule plus-ends [1].
Distinct mechanisms govern the localisation of Drosophila CLIP-190 to unattached kinetochores and microtubule plus-ends [1].

Biological context of CLIP-190

During mitosis, CLIP-190 localises to unattached kinetochores independently of spindle-checkpoint activation [1].
In addition, we found that CLIP-190 association to microtubule plus-ends is regulated during the cell cycle [1].

Anatomical context of CLIP-190

The localisation of CLIP-190 to such microtubules and to the fusome is dependent upon Orbit/Mast to which it is complexed [4].

References

Distinct mechanisms govern the localisation of Drosophila CLIP-190 to unattached kinetochores and microtubule plus-ends. Dzhindzhev, N.S., Rogers, S.L., Vale, R.D., Ohkura, H. J. Cell. Sci. (2005) [Pubmed]
MAST/Orbit has a role in microtubule-kinetochore attachment and is essential for chromosome alignment and maintenance of spindle bipolarity. Maiato, H., Sampaio, P., Lemos, C.L., Findlay, J., Carmena, M., Earnshaw, W.C., Sunkel, C.E. J. Cell Biol. (2002) [Pubmed]
A class VI unconventional myosin is associated with a homologue of a microtubule-binding protein, cytoplasmic linker protein-170, in neurons and at the posterior pole of Drosophila embryos. Lantz, V.A., Miller, K.G. J. Cell Biol. (1998) [Pubmed]
Orbit/Mast, the CLASP orthologue of Drosophila, is required for asymmetric stem cell and cystocyte divisions and development of the polarised microtubule network that interconnects oocyte and nurse cells during oogenesis. Máthé, E., Inoue, Y.H., Palframan, W., Brown, G., Glover, D.M. Development (2003) [Pubmed]

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