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Gene Review

Eb1  -  CG3265 gene product from transcript CG3265-RF

Drosophila melanogaster

Synonyms: BcDNA.LD08743, BcDNA:LD08743, CG3265, Dm EB1, DmEB1, ...
 
 
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High impact information on Eb1

  • Our data also suggest that KLP10A is deposited on microtubules by the plus-end tracking protein, EB1 [1].
  • In yeast, the EB1 homologue (BIM1) has been shown to modulate microtubule dynamics and link microtubules to the cortex, but the functions of metazoan EB1 proteins remain unknown [2].
  • Similar phenotypes were observed in mitotic spindles of Drosophila embryos that were microinjected with anti-EB1 antibodies [2].
  • Despite intense studies carried out in yeast and cultured cells, the role of EB1 in multicellular systems remains to be elucidated [3].
  • Drosophila RhoGEF2 associates with microtubule plus ends in an EB1-dependent manner [4].
 

Biological context of Eb1

  • Shot forms a protein complex with EB1 via its C-terminal EF-hands and GAS2-containing domains [5].
  • Our results reveal crucial roles for EB1 in mitosis, which we postulate involves its ability to promote the growth and interactions of microtubules within the central spindle and at the cell cortex [2].
 

Anatomical context of Eb1

 

Co-localisations of Eb1

  • We show that Shot colocalizes with EB1/APC1 and with a compact microtubule array extending between the muscle-tendon junction and the cuticle [5].
 

Other interactions of Eb1

  • Another microtubule plus-end tracking protein, EB1, directly interacts with the CAP-Gly domain of CLIP-190 and is required to localise CLIP-190 at microtubule plus-ends [6].
  • New findings reveal that the cytoskeletal linker protein Short stop works with EB1 and APC1 to help carry out this function [7].

References

  1. Functionally distinct kinesin-13 family members cooperate to regulate microtubule dynamics during interphase. Mennella, V., Rogers, G.C., Rogers, S.L., Buster, D.W., Vale, R.D., Sharp, D.J. Nat. Cell Biol. (2005) [Pubmed]
  2. Drosophila EB1 is important for proper assembly, dynamics, and positioning of the mitotic spindle. Rogers, S.L., Rogers, G.C., Sharp, D.J., Vale, R.D. J. Cell Biol. (2002) [Pubmed]
  3. EB1 is essential during Drosophila development and plays a crucial role in the integrity of chordotonal mechanosensory organs. Elliott, S.L., Cullen, C.F., Wrobel, N., Kernan, M.J., Ohkura, H. Mol. Biol. Cell (2005) [Pubmed]
  4. Drosophila RhoGEF2 associates with microtubule plus ends in an EB1-dependent manner. Rogers, S.L., Wiedemann, U., Häcker, U., Turck, C., Vale, R.D. Curr. Biol. (2004) [Pubmed]
  5. Shortstop recruits EB1/APC1 and promotes microtubule assembly at the muscle-tendon junction. Subramanian, A., Prokop, A., Yamamoto, M., Sugimura, K., Uemura, T., Betschinger, J., Knoblich, J.A., Volk, T. Curr. Biol. (2003) [Pubmed]
  6. Distinct mechanisms govern the localisation of Drosophila CLIP-190 to unattached kinetochores and microtubule plus-ends. Dzhindzhev, N.S., Rogers, S.L., Vale, R.D., Ohkura, H. J. Cell. Sci. (2005) [Pubmed]
  7. Cytoskeletal connections: building strong cells in new ways. Grevengoed, E.E., Peifer, M. Curr. Biol. (2003) [Pubmed]
 
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