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Gene Review

KAAG1  -  kidney associated antigen 1

Homo sapiens

Synonyms: Kidney-associated antigen 1, RU2, RU2 antisense gene protein, RU2AS
 
 
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High impact information on KAAG1

  • It is encoded by an antisense transcript, RU2AS, which starts from a cryptic promoter located on the reverse strand of the first intron and ends up on the reverse strand of the RU2S promoter, which contains a polyadenylation signal [1].
  • Short-term cultures of normal epithelial cells from the renal proximal tubule expressed significant levels of RU2AS message and were recognized by the CTLs [1].
  • The RU2 elements in the hypervariable S232 loci on the X chromosome consist of repeating sequences which are highly asymmetric, with about 90% purines and no C's on one strand [2].
  • Restriction mapping and sequence analysis show that each S232 unit contains 5 kb of unique sequence in addition to two elements, RU1 and RU2, composed of a variable number of tandem repeats [2].
  • Although the repeating units of the RU2 elements in the nonpolymorphic S232 loci on the Y chromosome share high sequence homology with those on the X chromosome, they exhibit much higher intrarepeat sequence variation [2].
 

Anatomical context of KAAG1

  • 3. RU1 and RU2 were also generated from [(14)C]M17055 after incubation with human liver microsomes, suggesting that the metabolic pathway of M17055 in humans involves that observed in rats [3].

References

  1. A new antigen recognized by cytolytic T lymphocytes on a human kidney tumor results from reverse strand transcription. Van Den Eynde, B.J., Gaugler, B., Probst-Kepper, M., Michaux, L., Devuyst, O., Lorge, F., Weynants, P., Boon, T. J. Exp. Med. (1999) [Pubmed]
  2. Characterization of a low copy repetitive element S232 involved in the generation of frequent deletions of the distal short arm of the human X chromosome. Li, X.M., Yen, P.H., Shapiro, L.J. Nucleic Acids Res. (1992) [Pubmed]
  3. Studies on the metabolic fate of M17055, a novel diuretic (4): species difference in metabolic pathway and identification of human CYP isoform responsible for the metabolism of M17055. Nakajima, H., Nakanishi, T., Nakai, K., Matsumoto, S., Ida, K., Ogihara, T., Ohzawa, N. Drug Metab. Pharmacokinet. (2002) [Pubmed]
 
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