High impact information on CSR

• Thus, the age-related impairment of type II up-regulation may reflect an intrinsic deficit in CSR biosynthesis or lability that is independent of the acute endogenous adrenal steroid environment [1].
• The rat hippocampus contains at least two types of CSR binding and differential analysis of types I and II CSR was accomplished by selective displacement of [3H]corticosterone with RU-28362, a specific type II agonist [1].
• This study examined the ability of orally self-administered ethanol to establish a tone-light stimulus complex as a conditioned reinforcer (CSR) [2].
• CSR specifically binds to two regions in the calcitonin-specific exon 4 RNA previously demonstrated to function as a bipartate exonic splice enhancer (ESE) [3].

Biological context of CSR

• However, in aged (24-26 months old) rats, type II CSR up-regulation did not occur over the 10 day post-ADX period [1].

Anatomical context of CSR

• In young (3 months old) Fischer-344 rat hippocampus, up-regulation of type II binding above 2-day ADX baseline was present by 3-7 days and increased still further by 8-10 days post-ADX; type I CSR density did not change significantly between 1 and 10 days post-ADX [1].

Regulatory relationships of CSR

• A candidate calcitonin/CGRP splice regulator (CSR) isolated from rat brain was shown to inhibit calcitonin-specific splicing in vitro [3].

Analytical, diagnostic and therapeutic context of CSR

• In order to assess the effects of age on CSR biosynthetic capacity in the absence of down-regulatory influences of endogenous corticoids, as well as to study aging changes in CSR plasticity, we examined the up-regulation of hippocampal CSR that follows adrenalectomy (ADX) [1].

References