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Gene Review

Dap160  -  Dynamin associated protein 160

Drosophila melanogaster

Synonyms: CG1099, DAP-160, DAP160, Dap160/intersectin, Dmel\CG1099, ...
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High impact information on Dap160


Associations of Dap160 with chemical compounds

  • For example, p160 class coactivators associate with histone acetyltransferases and arginine histone methyltransferases [5].

Physical interactions of Dap160

  • As anticipated, the NPF motifs in STNB are found to be high-affinity binding motifs for the EH domains of DAP-160 [6].


  1. Dap160/intersectin acts as a stabilizing scaffold required for synaptic development and vesicle endocytosis. Koh, T.W., Verstreken, P., Bellen, H.J. Neuron (2004) [Pubmed]
  2. Dap160/intersectin scaffolds the periactive zone to achieve high-fidelity endocytosis and normal synaptic growth. Marie, B., Sweeney, S.T., Poskanzer, K.E., Roos, J., Kelly, R.B., Davis, G.W. Neuron (2004) [Pubmed]
  3. The Competence Factor {beta}Ftz-F1 Potentiates Ecdysone Receptor Activity via Recruiting a p160/SRC Coactivator. Zhu, J., Chen, L., Sun, G., Raikhel, A.S. Mol. Cell. Biol. (2006) [Pubmed]
  4. The endocytic machinery in nerve terminals surrounds sites of exocytosis. Roos, J., Kelly, R.B. Curr. Biol. (1999) [Pubmed]
  5. Methylation at lysine 4 of histone H3 in ecdysone-dependent development of Drosophila. Sedkov, Y., Cho, E., Petruk, S., Cherbas, L., Smith, S.T., Jones, R.S., Cherbas, P., Canaani, E., Jaynes, J.B., Mazo, A. Nature (2003) [Pubmed]
  6. Molecular and genetic characterization of the interactions between the Drosophila stoned-B protein and DAP-160 (intersectin). Kelly, L.E., Phillips, A.M. Biochem. J. (2005) [Pubmed]
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