High impact information on Dap160

• Our data suggest that Dap160, like dynamin, is involved in synaptic vesicle retrieval at active and periactive zones [1].
• Dap160/intersectin scaffolds the periactive zone to achieve high-fidelity endocytosis and normal synaptic growth [2].
• The dap160 mutant synapse is grossly malformed with abundant, highly ramified, small synaptic boutons [2].
• The Competence Factor {beta}Ftz-F1 Potentiates Ecdysone Receptor Activity via Recruiting a p160/SRC Coactivator [3].
• In Drosophila neuromuscular junctions, the multi-domain protein Dap160 is also localized to hot spots [3] and has some characteristics expected of an anchoring protein [4].

Associations of Dap160 with chemical compounds

• For example, p160 class coactivators associate with histone acetyltransferases and arginine histone methyltransferases [5].

Physical interactions of Dap160

• As anticipated, the NPF motifs in STNB are found to be high-affinity binding motifs for the EH domains of DAP-160 [6].

References