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Gene Review

Itsn1  -  intersectin 1 (SH3 domain protein)

Rattus norvegicus

Synonyms: EH domain and SH3 domain regulator of endocytosis 1, Ehsh1, Intersectin-1, Itsn
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High impact information on Itsn1

  • Our data suggest that EHSH1/intersectin may be a novel adaptor protein that couples endocytic membrane traffic to exocytosis [1].
  • Immunofluorescence analysis of cultured hippocampal neurons reveals that intersectin is found at the plasma membrane where it is co-localized with clathrin [2].
  • Using a newly developed intersectin antibody, we demonstrate that endogenous COS-7 cell intersectin localizes to clathrin-coated pits, and transfection studies suggest that the EH domains may direct this localization [2].
  • Through alternative splicing in a stop codon, a long form of intersectin is generated with a C-terminal extension containing Dbl homology (DH), pleckstrin homology (PH), and C2 domains [2].
  • We recently identified and cloned intersectin, a protein containing two Eps15 homology (EH) domains and five Src homology 3 (SH3) domains [2].

Biological context of Itsn1

  • Neuronal distribution of EHSH1/intersectin: molecular linker between clathrin-mediated endocytosis and signaling pathways [3].

Analytical, diagnostic and therapeutic context of Itsn1

  • Western blots reveal that the long form of intersectin is expressed specifically in neurons, whereas the short isoform is expressed at lower levels in glia and other nonneuronal cells [2].


  1. EHSH1/intersectin, a protein that contains EH and SH3 domains and binds to dynamin and SNAP-25. A protein connection between exocytosis and endocytosis? Okamoto, M., Schoch, S., Südhof, T.C. J. Biol. Chem. (1999) [Pubmed]
  2. Splice variants of intersectin are components of the endocytic machinery in neurons and nonneuronal cells. Hussain, N.K., Yamabhai, M., Ramjaun, A.R., Guy, A.M., Baranes, D., O'Bryan, J.P., Der, C.J., Kay, B.K., McPherson, P.S. J. Biol. Chem. (1999) [Pubmed]
  3. Neuronal distribution of EHSH1/intersectin: molecular linker between clathrin-mediated endocytosis and signaling pathways. Ma, Y.J., Okamoto, M., Gu, F., Obata, K., Matsuyama, T., Desaki, J., Tanaka, J., Sakanaka, M. J. Neurosci. Res. (2003) [Pubmed]
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